• Basic principles of animal models
• 35 min
  1. Quality and validity in animal research

  • Dr. Anna Olsson
• 32 min
  2. The moral status of invasive animal research

  • Prof. Bernard E. Rollin
• 35 min
  3. Legal aspects of using animals for research in the U.S.

  • Dr. B. Taylor Bennet
• 54 min
  4. Legal and ethical aspects of using animals in research in the EU

  • Dr. Judy A. MacArthur Clark
• 43 min
  5. Anesthesia

  • Prof. Luis Antunes
• 46 min
  6. Analgesia, anesthesia monitoring and perioperative care

  • Prof. Luis Antunes
• 48 min
  7. Modern production of laboratory animals

  • Dr. Martin Toft
• 24 min
  8. The 3Rs of animal research & beyond

  • Prof. Dave Lewis
• Modern techniques for the creation of animal models
• 51 min
  9. Creating animal models by genetic techniques

  • Mr. Emmanuel Gomas
• 48 min
  10. Surgical models and perioperative care in swine

  • Prof. M. Michael Swindle
  • Prof. Mary Ann McCrackin
• 42 min
  11. Improving and humanizing animal models by microbiomic techniques

  • Prof. Axel Kornerup Hansen
• Specific animal models
• 51 min
  12. Behavioral phenotyping of mouse models of neuropsychiatric and neurodevelopmental disorders

  • Prof. Jacqueline N. Crawley
• 32 min
  13. Hormones, feeding and animal models

  • Prof. Carel le Roux
• 47 min
  14. Animal models for rheumatoid arthritis

  • Prof. Rikard Holmdahl
• 40 min
  15. Development of immunotherapies for type 1 diabetes. Value and limitations of mouse models.

  • Prof. Matthias von Herrath
• 32 min
  16. Animal models of inflammatory bowel disease

  • Dr. Anje te Velde
• 33 min
  17. Animal models for schizophrenia

  • Dr. Mikhail Pletnikov
• 41 min
  18. Animal models of seizures and epilepsy

  • Dr. Wolfgang Löscher

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Schizophrenia
3. Modeling schizophrenia
4. Non-genetic models
5. Pharmacological models (1)
6. Pharmacological models (2)
7. Pharmacological models (3)
8. Symptoms similarity models (1)
9. Mouse sociability test
10. Symptoms similarity models (2)
11. Etiological non-genetic models (1)
12. Etiological non-genetic models (2)
13. Etiological non-genetic models (3)
14. Etiological non-genetic models (4)
15. Genetic models (1)
16. Genetic models (2)
17. Genetic models (3)
18. Genetic models (4)
19. Genetic models: Genome-wide association
20. Genetic models: Copy number variation (1)
21. Genetic models: Copy number variation (2)
22. Genetic models: Linkage studies
23. DISC1 gene
24. DISC1 animal models
25. Inducible mutant DISC1 model
26. Tet-off system (1)
27. No gross developmental defects
28. Hyperactivity
29. Elevated aggressiveness
30. Enlargement of the lateral ventricles (1)
31. The nature of DISC1 animal model
32. Why study timing?
33. Tet-off system (2)
34. Aggression in male mice
35. Enlargement of the lateral ventricles (2)
36. Caveats of genetic mouse models
37. New approaches (1)
38. New approaches (2)
39. Gene-environment interaction (GEI) models
40. Challenges of GEI models
41. Concluding remarks
42. Acknowledgements

Topics Covered

• Animal models for schizophrenia
• Animal models of psychiatric disorders
• Non-genetic animals models
• genetic animal models
• DISC1 anima models
• Weaknesses of the current animal models for schizophrenia
• Future directions in developing animal models for schziophrenia

Links

Series:

• Animal Models in Biomedical Research
• Drug Discovery and Development in the Neurosciences

Categories:

• Methods
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 28, 2013

Financial Disclosures

• Dr. Mikhail Pletnikov has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.