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1. Introduction
2. Lecture outline
3. Macrophages - general attributes
4. Macrophages and receptor recognition
5. CD36 structure
6. CD36: regions within the protein
7. CD36: function and membrane distribution
8. CD36: a multifunctional membrane glycoprotein (1)
9. CD36: a multifunctional membrane glycoprotein (2)
10. Atherogenesis and monocytes/macrophages
11. A tale of two mice
12. Experimental design of atherosclerosis in mice
13. The aortic tree in mice and humans
14. Absence of CD36 & atherosclerosis in apoEo mice
15. ApoEo vs. ApoEo/CD36o: degree of lesions
16. Lesions in LDLRo mice are not CD36 dependent
17. LDLRo vs. LDLRo/CD36o lesion burden
18. Foam cell formation in LDLRo is CD36 dependent
19. CD36 may not be the atherogenic ligand in LDLRo
20. In vivo foam cell assay
21. The ligand in the 2 mouse models differs
22. Ligand may differ in a CD36 dependent manner
23. Making the LDL in the LDLRo a ligand for CD36
24. LDLRo vs. CD36o/LDLRo + high cholesterol diet
25. LDLR KO's: hyperlipidemia and inflammation
26. Inflammation, CD36 ligands and atherosclerosis
27. CD36 specific ligands in oxidatively modified LDL
28. CD36 ligands are choline glycerophospholipids
29. How CD36 detects differences in phospholipids
30. Multiple pathways may create CD36R ligands
31. Recognition of altered self ligands by CD36
32. Summary
33. Acknowledgements

Topics Covered

• Scavenger receptors
• Structure of CD36
• Role of CD36
• The link between inflammation and CD36
• Risk factors for inflammation

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Immunology

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation

Talk Citation

Publication History

• Published on January 30, 2013

Financial Disclosures

• Dr. Maria Febbraio has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.