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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
-
30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
-
24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Definition
- Standardisation of the technique
- Methods of sputum induction and processing
- Facilities and instruments required
- Sputum induction method
- Alternative method of sputum induction
- Key points (1)
- Treatment with salbutamol and saline
- Sputum induction shouldn't be repeated frequently
- Repeated inductions
- Sputum composition changes
- Interferences among sputum induction
- Methods of sputum processing
- Characteristics of a sputum sample
- Instruments needed to evaluate a sample
- Two methods for processing sputum (1)
- Two methods for processing sputum (2)
- Sputum processing with DTT
- Processing sputum samples
- Key points (2)
- Comparison of two methods of processing (1)
- The methods are not interchangeable
- Safety
- Safety and reproducibility of sputum induction
- Key points (3)
- Pretreatment with a short-acting Beta 2-agonist
- Predictors of excessive bronchoconstriction
- No reports of death or hospital admission
- Full resuscitation equipment should be available
- Reproducibility
- Reproducibility between sample
- Validity and application in asthma
- Comparison with other techniques
- Comparing induced sputum and other methods
- A correlation between eNO & sputum eosinophils
- Eosinophil count and exhaled breath condensate
- Comparing methods - summary
- Reference values
- Induced sputum cellularity
- Differential cell count - normal values
- Induced sputum cells in healthy controls
- The influence of age
- Disease vs. healthy
- Comparison of two methods of processing (2)
- Sputum eosinophil counts in asthma
- Controlled vs. not controlled asthma
- Sputum neutrophil counts in asthma
- Sensitivity to risk factors or treatment
- Analysis of cellular and biochemical constituents
- Effects of prednisone on airway inflammation
- Inhaled steroids and induced sputum eosinophils
- Effects of anti-IgE omalizumab on inflammation
- Targeted therapy with anti-IL5 in asthma
- Eosinophils predicts response to corticosteroids
- Clinical use
- Asthma exacerbations and eosinophil counts
- A randomised controlled trial
- A randomised controlled trial - eosinophil count
- A randomised controlled trial - exacerbations
- Summary (1)
- Summary (2)
Topics Covered
- Induced Sputum: facilities and procedure
- Induced Sputum as a biomarker of airway disease in asthma
- Comparison with other techniques
- Reference values and comparison between healthy and patients
- Induced sputum in asthma: clinical implications
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Spanevello, A. (2013, January 17). Induced sputum in asthma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/BVJF3052.Export Citation (RIS)
Publication History
- Published on January 17, 2013
Financial Disclosures
- Prof. Antonio Spanevello has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
