• View the Talks
• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Severe combined immunodeficiency
3. Diseases associated with IL-7R polymorphisms
4. Thymic defect in IL-7R-/- mice
5. Gene therapy of SCID
6. Gene therapy and cancer risk
7. Gamma-c cytokine receptors
8. IL7 receptor knockout
9. IL7 ligand knockout
10. Effect of IL-7 survival of pro-T subsets
11. Bcl-2 family of anti and pro-apoptotic proteins
12. Trophic factor & mitochondrial damage
13. Bcl-2 promotes D1 cell survival
14. Bax deficiency restores T cell development
15. The effect of IL-7 withdrawal
16. IL-7R mutants from human T-ALL
17. Mutant hIL-7R and ligand-independent signaling
18. D1 cells with mutant hIL-7R induce tumors in vivo
19. Mutant IL-7R converts D1 to tumor-forming cells
20. Hematopoietic neoplasm in multiple organs
21. hIL-7Ralpha mutants promote dimerization
22. Mutant IL-7Ralpha model
23. Exon 6 of IL-7Ralpha (1)
24. Exon 6 of IL-7Ralpha (2)
25. Lymphocyte homeostasis
26. Homeostatic correction
27. Resource limitation example (1)
28. Resource limitation example (2)
29. Resource limitation example (3)
30. Resource limitation example (4)
31. Resource limitation example (5)
32. Resource limitation example (6)
33. IL-7 and nave CD8 homeostasis
34. Classical proliferation pathway model
35. IL-7/IL-3 proliferation pathway model (1)
36. IL-7/IL-3 proliferation pathway model (2)
37. IL-7/IL-3 proliferation pathway illustration
38. Thymic cells expressing knock-in IL-7-CFP
39. Class II MHC expression on thymic epithelium
40. Class II MHC expression on skin dendritic cells
41. Developing thymocides grow in a matrix
42. Matrix nature
43. Thymic epithelial cell matrix
44. Looking down through the matrix
45. In the embryonic thymus
46. IL-7-CFP knock-in
47. IL-7 in the bone marrow
48. rhIL-7 increases in vivo TCR repertoire diversity
49. IL-7 drives T cell-cycle entry & expansion in HIV-1
50. Progressive multifocal leukoencephalopathy
51. IL-7 improves survival in sepsis
52. Treatment with IL-7 inhibitors
53. Acknowledgments
54. Producing cytokines painting

Topics Covered

• IL-7 in T cell development
• IL-7R in leukemia
• IL-7 in T cell homeostasis
• IL-7-expressing cells

Links

Series:

• Cytokines

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on December 18, 2012

Financial Disclosures

• Dr. Scott Durum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.