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1. Introduction
2. Complex carbohydrates
3. Glycocalyx: the cell surface carbohydrate layer
4. Cell surface carbohydrate interactions
5. Biosynthesis of oligosaccharides
6. Many tumor markers are Carbohydrates
7. Pathogens infecting by carbohydrate recognition
8. Lectins: native carbohydrate-binding proteins
9. The selectins are therapeutic targets
10. Enhancing carbohydrate-lectin interaction
11. Bioactive conformation of glycomimetic 69669a
12. Preorganization of the bioactive conformation
13. Enhancing binding affinity for E-selectin
14. E & P-selectins binding to native ligand PSGL-1
15. Glycosylation and sulfation of PSGL-1
16. Sulfated drug-like fragment-based library
17. GMI-1070 is a pan selectin antagonist
18. GMI-1070: pre-clinical models
19. Effect of GMI-1070 animal models
20. Sickle cell Vaso-Occlusive Crisis (VOC)
21. Testing the effects of GMI-1070 on VOC
22. GMI-1070 for vaso-occlusive crisis
23. Effects of GMI-1070 in sickle cell mice
24. GMI-1070 extends survival in sickle cell mice
25. GMI-1070- synthesized through convergent steps
26. Scale-up chemistry and process development
27. Organizations involved in GMI-1070 synthesis
28. GMI-1070: phase I clinical trial
29. Pharmacokinetics of a single dose of GMI-1070
30. Phase 1 healthy volunteers - safety summary
31. Clinical trials testing effects of GMI-1070
32. GMI-1070: summary
33. Validation of the potential of glycomimetic drugs
34. Summary
35. Scientific contributors

Topics Covered

• Glycobiology as an untapped source of innovative drugs
• Rationally designed selectin antagonists based on functional carbohydrates
• Application to inflammation in sickle cell disease crisis
• Drug-like properties now in Phase II clinical trials
• Recognition and validation of glycomimetic drugs by the pharmaceutical industry

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Pharmaceutical Sciences

Talk Citation

Magnani, J. (2012, November 27). Glycobiology: an untapped source of novel drugs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/TTKR2837.
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Publication History

• Published on November 27, 2012

Financial Disclosures

• Dr. John Magnani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.