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1. Introduction
2. Aberrant glycosylation is an oncogenesis hallmark
3. Cell transformation & glycoconjugate biosynthesis
4. Aberrant glycosylation & blood group expression
5. Study by Hajime Masamune
6. Cancer and healthy cells show difference in lectin
7. Cancer glycosignatures in transformed cells
8. Human and mouse glycan-related genes
9. Small sample of glycosyltransferase reactions
10. Alteration of glycan expression
11. Understanding altered glycans during oncogenesis
12. Glycan changes in breast cancer
13. Aberrant N-glycan branching during oncogenesis
14. The N-linked glycan synthesized by GnT-V
15. L-PHA binding to breast tissue sections
16. The signaling pathway of GnT-V expression
17. GnT-V up-regulation in cancer tissues
18. GnT-V expression levels regulate cell-cell adhesion
19. Glycan-driven feedback amplification loop
20. GnT-V is a multi-function controller
21. GnT-V deletion delayed her-2-induced tumor onset
22. GnT-V deletion reduced tumor initiating cells (TIC)
23. Identifying potential biomarkers of breast cancer
24. Depicting targeted glycoproteomics with L-PHA
25. Identification of GnT-V products in tissue extracts
26. Tumor-specific glycoproteins bound to L-PHA
27. Information on the glycoprotein periostin
28. Recent data on periostin and cancer stem cells
29. Glycosyltransferase loss in oncogenesis
30. Tn and sialyl Tn antigens cell surface expression
31. Overview of Tn & STn expression in human cancer
32. O-glycan structures
33. Biosynthesis of O-glycans
34. Cosmc - a specific chaperone of T-synthase
35. Dysfunctional Cosmc & Tn and sialyl Tn antigens
36. Effects of loss of T-synthase
37. Acknowledgements
38. References (1)
39. References (2)
40. References (3)

Topics Covered

• Glycomics
• Tumor-specific glycoproteins
• Aberrant glycosylation
• Understanding altered glycans during oncogenesis
• Glycosyltransferase
• GnT-V in oncogenesis
• L-PHA in cancer
• Tn and sialyl Tn antigens
• O-glycan structures
• Dysfunctional Cosmc
• Loss of T-synthase
• Overexpression of Periostin

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cancer
• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Michael Pierce has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.