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1. Introduction
2. Cardiovascular disease
3. Cardiovascular tissue engineering
4. Hilton head panel discussion
5. Coronary bypass
6. Functional blood vessel substitute
7. Tissue engineering: a blood vessel substitute
8. Cell source can be a "show stopper"
9. The vascular endothelial cell
10. Some issues related to cell source
11. Use of autologous cells
12. Use of allogeneic cells
13. Bone marrow-derived cells
14. Circulating endothelial progenitor cells
15. Von Willebrand factor
16. Shear stress effect on expression
17. Baboon external shunt studies
18. The process used in external shunt studies
19. CEC construct preconditioned to arterial shear
20. Recruitment of circulating cells
21. Endothelial cells
22. "Flavors" of pluripotency exist
23. In vitro differentiation: from ES to endothelial cells
24. ES-derived endothelial cells elongation
25. Scaffolds in tissue repair/replacement
26. Some biological scaffolds
27. The matrix and cell function
28. Acellular scaffolds
29. Collagen-based blood vessel model
30. Weinberg and Bell
31. Bioreactor system
32. Construction of a well-formed blood vessel wall
33. Polymer scaffold-based construct
34. Laura Niklason laboratory
35. Donor age effect on vessel engineering
36. Auger and co-workers
37. Auger's team approach for tissue engineering
38. A concept for blood vessel tissue engineering
39. Bioreactor technology
40. In vivo versus in vitro remodeling
41. Development of a cell-seeded scaffold
42. Engineering immune acceptance
43. Road to engineered tissue constructs and tolerance
44. Clinical applications
45. In vitro results of ePTFE grafts endothelialization
46. Influence of graft diamer on ePTFE grafts patency
47. Women's Medical University results of clinical trials
48. Summary

Topics Covered

• Tissue engineering approaches
• Different cell sources for a blood vessel substitute
• Circulating endothelial progenitor cells: their characteristics, their use in a blood cell substitute and recruitment from the host circulating blood
• Differentiation from ES into endothelial cells in vitro and their endothelial-like characterization
• The use of different types of scaffolds
• In vivo and in vitro remodeling
• Engineering immune acceptance
• Clinical applications: EC-seeded ePTFE grafts for peripheral applications and cell-seeded polymer scaffold grafts for pulmonary artery/Fontan procedure

Links

Series:

• Stem Cells and Regenerative Medicine

Categories:

• Cell Biology
• Methods

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Robert Nerem has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.