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1. Introduction
2. What are GPI membrane anchors?
3. How are proteins bound to membranes?
4. Examples of GPI-anchored proteins (1)
5. Examples of GPI-anchored proteins (2)
6. Examples of GPI-anchored proteins (3)
7. Features of GPI-anchored proteins
8. GPI transamidase
9. GPI-anchored protein biosynthesis (1)
10. GPI-anchored protein biosynthesis (2)
11. GPI-anchored protein biosynthesis (3)
12. GPI-anchored protein biosynthesis (4)
13. GPI-anchored protein biosynthesis (5)
14. GPI-anchored protein biosynthesis (6)
15. Lipid remodeling reactions
16. General structure of GPI anchors
17. Introduction to the African trypanosome
18. Human African Sleeping Sickness
19. Trypanosome TEM & SEM images
20. The trypanosome surface coat (1)
21. The trypanosome surface coat (2)
22. The trypanosome surface coat (3)
23. The trypanosome VSG GPI anchor
24. How the GPI structure was determined
25. Remove contaminants
26. Find some associations
27. Find some more associations
28. Complete the associations with NMR and MS
29. GPI reactions for structure determination
30. Solved GPI structures (1)
31. Solved GPI structures (2)
32. Differences in parasite and host GPI pathways
33. The cell-free system
34. The modified cell-free system
35. The synthesis of GPI substrates and analogues
36. Examples of GPI biosynthesis experiments
37. Features in GPI pathway substrate recognition
38. GlcNAc-PI de-N-acetylase as a drug target
39. Crosslinking of GPI anchored proteins
40. General functions of GPI anchors
41. Lipid rafts
42. Acknowledgments

Topics Covered

• What are GPI membrane anchors and examples of their occurrence
• The biosynthesis of GPI anchors
• The structure of GPI anchors and analytical methods
• Inhibitors of GPI biosynthesis as therapeutic agents
• Biological functions of GPI membrane anchors

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Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Michael Ferguson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.