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1. Introduction
2. Genomics and the future of psychiatry
3. Schizophrenia susceptibility genes
4. Common sequence variants in the genome
5. The GWAS approach (1)
6. The GWAS approach (2)
7. GWAS redux
8. The inconvenient truth of GWAS
9. Two questions and some answers
10. The path from here to there
11. MZ twins and schizophrenia (1)
12. MZ twins and schizophrenia (2)
13. Three key points in this talk
14. Abnormal behavior & abnormal brain function
15. Abnormal prefrontal "efficiency"
16. Cortical "efficiency" in Parkinson's disease
17. Effect of COMT val/met genotype
18. CACNA1C modulates cortical efficiency
19. Simple behaviors & processing networks
20. Dysfunction of a prefrontal-limbic network
21. Effect of ZNF804A on cortical dynamics
22. Genetic association & brain function: caveats
23. Prefrontal-hippocampal coupling dynamics
24. Prefrontal efficiency and connectivity
25. ZNF804A risk associated SNP
26. Realistic phenotypic models
27. Dynamic modeling of "effective connectivity"
28. Dissociating maintenance from work
29. Modeling of cortical-striatal network activity
30. COMT, DRD2, and AKT1 polymorphisms
31. COMT modulates connectivity in maintenance
32. Complex behaviors result from multiple factors
33. Simple behaviors also involve complex networks
34. Complex profiles & risk assessment in epilepsy
35. DISC1 effect on dendrite is mediated by NKCC1
36. Epistatic interaction of NKCC1 and DISC1
37. ErbB4 signaling is a schizophrenia risk pathway
38. Epistatic interactions in NRG1-ERBB4-AKT1
39. Comparisons of genotype risk groups
40. Functional polymorphisms: 3 "psychiatric" genes
41. Epistasis of AKT1, BDNF and COMT
42. Higher order epistasis of COMT x BDNF x AKT1
43. Acknowledgements
44. Conclusions

Topics Covered

• Genomics and the future of psychiatry
• Schizophrenia susceptibility genes
• The GWAS approach
• Behavior, brain functions & networks
• Efficiency, dynamics & connectivity of different brain areas
• Realistic phenotypic models
• Polymorphisms and "psychiatric" genes
• Epistatic interactions between various genes
• Comparisons of genotype risk groups

Links

Series:

• Biomarkers

Categories:

• Genetics & Epigenetics
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Weinberger, D. (2012, November 18). Gene networks, brain networks: understanding schizophrenia [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 26, 2024, from https://doi.org/10.69645/KGPV1056.
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Publication History

• Published on November 18, 2012

Financial Disclosures

• Dr. Daniel Weinberger has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.