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Printable Handouts
Navigable Slide Index
- Introduction
- The endoplasmic reticulum (1)
- The endoplasmic reticulum (2)
- Endoplasmic reticulum luminal environment
- The sarcoplasmic reticulum
- Calcium and cardiac pathology
- Calreticulin deficient embryos
- Incomplete development of septum
- Agonist calcium release in mutant cells
- Calcium dependent transcription factors
- Impact of calreticulin on Ca2+ homeostasis
- Calreticulin deficiency loss of function
- Embryonic stem cells studies
- ES cell derived embryoid body
- Isolated ES cell-derived cardiomyocytes
- Differentiation without calreticulin
- Incorrectly formed sarcomeric structures
- Important domains
- Calcium and cardiogenesis
- Calreticulin is critical for cardiogenesis
- Impact of increased level of calreticulin
- Reduced SOCE in calreticulin expressing cells
- Calreticulin gain of function
- Gain of function and disease
- Embryonic stem cells and gain of function
- Contractile function
- MHC promoter activity
- Pacemaker cells
- The cardiac conductive system
- Tamoxifen inducible calreticulin mice
- Dilated cardiomyopathy and fibrosis
- Dilated cardiomyopathy and heart failure
- Cardiac hypertrophy genes
- Membrane associated proteins
- Summary of talk
- Take home message
Topics Covered
- Molecular studies on the endoplasmic reticulum (ER) function and ER associated chaperones including calreticulin
- ER-associated functions are crucial in cardiac physiology and pathology -ER stress responses
- ER calcium buffering proteins impact many cardiac functions including cardiogenesis, ischemia and reperfusion, cardiomyopathies and heart failure
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Talk Citation
Michalak, M. (2012, October 31). Ca2+, the endoplasmic reticulum and cardiac pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/JRNE8292.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Marek Michalak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.