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1. Introduction
2. The endoplasmic reticulum (1)
3. The endoplasmic reticulum (2)
4. Endoplasmic reticulum luminal environment
5. The sarcoplasmic reticulum
6. Calcium and cardiac pathology
7. Calreticulin deficient embryos
8. Incomplete development of septum
9. Agonist calcium release in mutant cells
10. Calcium dependent transcription factors
11. Impact of calreticulin on Ca2+ homeostasis
12. Calreticulin deficiency loss of function
13. Embryonic stem cells studies
14. ES cell derived embryoid body
15. Isolated ES cell-derived cardiomyocytes
16. Differentiation without calreticulin
17. Incorrectly formed sarcomeric structures
18. Important domains
19. Calcium and cardiogenesis
20. Calreticulin is critical for cardiogenesis
21. Impact of increased level of calreticulin
22. Reduced SOCE in calreticulin expressing cells
23. Calreticulin gain of function
24. Gain of function and disease
25. Embryonic stem cells and gain of function
26. Contractile function
27. MHC promoter activity
28. Pacemaker cells
29. The cardiac conductive system
30. Tamoxifen inducible calreticulin mice
31. Dilated cardiomyopathy and fibrosis
32. Dilated cardiomyopathy and heart failure
33. Cardiac hypertrophy genes
34. Membrane associated proteins
35. Summary of talk
36. Take home message

Topics Covered

• Molecular studies on the endoplasmic reticulum (ER) function and ER associated chaperones including calreticulin
• ER-associated functions are crucial in cardiac physiology and pathology -ER stress responses
• ER calcium buffering proteins impact many cardiac functions including cardiogenesis, ischemia and reperfusion, cardiomyopathies and heart failure

Links

Series:

• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Michalak, M. (2012, October 31). Ca2+, the endoplasmic reticulum and cardiac pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/JRNE8292.
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Publication History

• Published on October 31, 2012

Financial Disclosures

• Prof. Marek Michalak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.