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1. Introduction
2. Stem cells: revolution in medicine
3. Organ regeneration - amphibians and mammals
4. Translation in order of probable success
5. Present results of clinical research
6. Different types of multi-potential stem cells
7. Novel problems in stem cell translational science
8. Traditional pharmacology vs. stem cells repair
9. Stem cells repair: the differences between organs
10. Mechanism of efficacy
11. Animal studies data - for and against stem cells
12. Human studies data - for and against stem cells
13. Lack of intellectual property
14. Cardiac therapeutics: small molecules
15. Gene therapy
16. Stem cell therapy
17. Doctors lead clinical development
18. Confusion among regulators
19. Interest among politicians: positive and negative
20. Present situation
21. Female heart transplanted to male:cell infiltration
22. The clinical trials - routes of stem cells delivery
23. Top Care - AMI studies - protocol
24. Top Care study: results
25. Top Care study: safety and clinical outcome
26. Summary of data from three studies
27. Plan for future clinical research
28. Gene transfer to stem cells
29. Conclusion

Topics Covered

• Amphibians and organ repair
• Application of different cell types to the heart in animal models
• Stem cell repair is complex
• The mechanism of efficacy is unknown
• Intellectual property in autologous stem cells
• Autologous bone marrow cells can cause an increase in ejection fraction after myocardial infarction
• Definitive randomised, controlled, blinded trials are needed
• Gene therapy plus stem cell therapy is the future

Links

Series:

• Stem Cells and Regenerative Medicine

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. John Martin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.