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1. Introduction
2. Cell-derived antibody concept
3. Serum protein electrophoresis (SPEP)
4. Structure of IgG molecule
5. Functional sites on the IgG molecule
6. IgM
7. Selected functions of Ig classes
8. Terminology
9. Major features of Fc-gamma receptors
10. Effector function by Fc-gamma receptors
11. Fc-gamma receptor signaling
12. Phosphorylated ITAMs
13. Phosphatidylinositol 3-kinase (PI 3-kinase)
14. Fc-gamma-R-mediated phagocytosis
15. ITAM inhibitory signaling
16. Fc-gamma-RIIB: an inhibitory Fc-gamma receptor
17. SHIP, an inositol 5' phosphatase
18. Fc-gamma-RIIB co-recruitment
19. Activating BCR and inhibitory Fc-gamma-RIIB
20. FcRn
21. Fc receptors: hypersensitivity and autoimmunity
22. Fc-epsilon-RI early signal transduction events
23. The Arthus reaction
24. Requirement of activating Fc-gamma-Rs (1)
25. Requirement of activating Fc-gamma-Rs (2)
26. Fc-gamma-RIIa alleles
27. Fc-gamma-RIIa
28. Fc-gamma-RIIb
29. Fc-gamma receptors hypothesis
30. Summary: Fc receptors
31. Biology of complement
32. Complement: early history
33. Recognized functions of complement
34. What is complement?
35. How complement contributes to host defense
36. Complement activation in host defense
37. The first step in complement cascade initiation
38. Proteolysis catalyzes complement activation
39. The core complement proteins
40. C1q
41. The classical pathway of complement activation
42. Steps in activation of C3
43. Similarities between C1 complex and MBL-MASP
44. Complement activation in antibodies absence
45. Complement activation - alternative pathway
46. All roads lead to Rome
47. C5a
48. Big MAC attack
49. Receptors for various complement components
50. CRIg
51. C3b and CR1
52. Clearance of immune complexes
53. Proteolytic fragments of the compliment C3
54. Positive and negative regulation of the BCR
55. Complement regulatory protein CD46 defect
56. Local production of complement proteins
57. Maximal co-stimulation requires complement
58. Complement regulatory proteins
59. Disposal of apoptotic debris
60. Defective apoptotic cell clearance consequences
61. Inherited complement deficiencies
62. Leukocyte adhesion deficiency (LAD)
63. Hereditary angioneurotic edema
64. Paroxysmal nocturnal hemoglobinuria
65. Summary: complement

Topics Covered

• Biology of Fc receptors
• Activating and inhibitory functions of Fc receptors
• Fc receptors in disease
• Biology of complement proteins
• Biology of complement receptors
• Complement receptors in disease

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Greenberg, S. (2012, September 10). The biology of Fc receptors and complement receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/DXGM5501.
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Publication History

• Published on September 10, 2012

Financial Disclosures

• Prof. Steven Greenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.