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1. Introduction
2. Objectives
3. Historical perspective
4. The developing immune system (1)
5. The developing immune system (1)
6. Why might kids be different?
7. Qualitative difference
8. Quantitative difference
9. Temporal difference
10. Global regulatory drivers and need for DIT testing
11. The concept of critical windows of development
12. A part of the Hematopoietic System
13. Critical windows of vulnerability (1)
14. Critical windows of vulnerability (2)
15. Critical windows of vulnerability (3)
16. Critical windows of development
17. Comparative immune system development
18. Rodent vs. human immune system
19. Non-human primate vs. human immune system
20. What's the evidence for a differential sensitivity
21. Differential sensitivity - lead
22. Differential sensitivity - TBTO
23. Evidence for differential sensitivity
24. Putative impact of xenobiotics
25. Dosing paradigms in historical DIT studies
26. What we know
27. Implications for immunotoxicity testing
28. In the context of human risk...
29. Assessing developmental immunotoxicity
30. The T-dependent antibody response (TDAR)
31. Splenic lymphocyte populations 10-day old rats
32. Splenic lymphocyte populations 21-day old rats
33. Functional assessment - humoral (1)
34. Functional assessment - humoral (2)
35. Functional assessment - cellular
36. Immunotoxicity across the developmental timeline
37. The word on immunopathology in rat
38. Other assessment possibilities
39. Study designs to assess DIT
40. Factors to consider in study design (1)
41. Factors to consider in study design (2)
42. Factors to consider in study design (3)
43. Stand-alone DIT study
44. Extended 1-generation reproductive toxicity study
45. Add-on to rat peri- and postnatal development
46. DIT in the nonhuman primate
47. Human health implications
48. Translational research
49. Risk assessment - what can we say?
50. Knowledge gaps and limitations
51. Acknowledgments
52. References

Topics Covered

• Historical background, regulatory and scientific
• Immune development across species
• Critical windows of immune system development
• Evidence for possible differential sensitivity -Methods to assess developmental immunotoxicity -Representative study designs -Risk evaluation
• Knowledge and data gaps

Links

Series:

• Non-Clinical Testing for Toxicity of Pharmaceuticals

Categories:

• Immunology
• Pharmaceutical Sciences

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Burns Naas, L.A. (2012, September 9). Toxicology of the developing immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/VRGT3800.
Export Citation (RIS)

Publication History

• Published on September 9, 2012

Financial Disclosures

• Dr. Leigh Ann Burns Naas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.