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Printable Handouts
Navigable Slide Index
- Introduction
- Importance of molecular chaperones
- Protein folding process
- Transitions during protein folding
- Protein folding in the cytosol
- Chaperone assisted protein folding: history
- Protein folding in vitro and in mitochondria
- Protein folding is often competed by aggregation
- The cellular environment is highly crowded
- Chaperone-assisted protein folding in E. coli
- Reconstitution of GroEL-assisted folding
- Early electron micrographs of GroEL
- GroES binds to the ends of the GroEL cylinder
- GroEL and GroES function as a folding cage
- GroEL structure
- Which proteins need GroEL/GroES for folding?
- Identification of the GroEL interaction proteome
- Class III substrates are of low cellular abundance
- Cellular depletion of GroEL/ES
- Size distribution of class III proteins
- Enrichment of TIM beta/alpha-barrel fold
- GroEL substrates have complex structures
- Chaperonins provide a folding environment
- GroEL as part of cytosolic chaperone network
- Cooperation of GroEL with upstream chaperones
- A summarizing movie
- Acknowledgements
Topics Covered
- De novo protein folding and proteome maintenance critically depend on molecular chaperones
- Transitions during protein folding
- Chaperone assisted protein folding
- Productive protein folding is often competed by aggregation
- Reconstitution of GroEL-assisted folding
- GroEL and GroES function as a folding cage for proteins up to 60 kDa
- GroEL structure
- Which proteins need GroEL/GroES for folding?
- Identification of the GroEL interaction proteome
- Class III substrates are of relatively low cellular abundance but occupy most of the GroEL capacity
- Chaperonins provide a specialized folding environment with two functional elements: sequestration and steric confinement in a hydrophilic cage
- GroEL as part of the cytosolic chaperone network
Talk Citation
Hartl, F.U. (2012, September 5). The interaction network of the GroEL chaperonin [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2021, from https://hstalks.com/bs/2384/.Publication History
Financial Disclosures
- Prof. Dr. F. Ulrich Hartl has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.