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1. Introduction
2. Exacerbations - a general definition
3. Severity of exacerbations of COPD
4. Early therapy improves exacerbation outcome
5. Treatment options for AECOPD
6. Triggers of COPD exacerbations
7. Etiology of AECOPD
8. Role of bacteria in AECOPD
9. Most common pathogens in COPD
10. Pseudomonas aeruginosa in COPD
11. Importance of bacterial & viral infections in COPD
12. RSV detection and COPD
13. Rhinovirus exposure impairs immune responses
14. Discolored sputum associate with more bacteria
15. Antibiotics and relapse rate association in AECB
16. Relapse rate for selected antibiotic groups
17. Use of antibiotics in mild form of exacerbations
18. Therapies for AECB according to patient subsets
19. COPD exacerbations: antibiotic therapy
20. Comparison of first vs. second line antibiotics
21. COPD exacerbation: antibiotics
22. Bacterial eradication improves symptoms
23. Moxifloxacin vs. macrolides
24. Relation of strep. resistance and macrolide use
25. Change in bacterial gene resistance
26. Antibiotics and therapy duration
27. Treatment failure in AECB
28. Moxifloxacin increases time to composite event
29. The ‘fall & rise’ of bacterial AECB
30. Risk of pneumonia in AECOPD
31. Systemic steroid vs. placebo in AECOPD
32. Benefit of systemic steroid use in AECOPD
33. Beta agonists
34. Clinical case (1)
35. Venturi mask
36. Clinical case (2)
37. Why is this patient more hypercapnic?
38. Ventilator management
39. COPD exacerbation: markers of severity
40. Treatments improving survival
41. Noninvasive ventilation (NIV)
42. Noninvasive vs. conventional ventilation
43. What are the contraindications for NIV
44. Noninvasive positive pressure masks
45. Ventilator settings
46. Algorithm for NIV management
47. Possible factors to consider in treatment failures
48. Pulmonary rehabilitation after exacerbations
49. COPD exacerbations: mortality
50. COPD exacerbations: survival
51. Conclusions

Topics Covered

• Treatment of COPD based on the underlying conditions
• The most important causes of COPD exacerbations: viral and bacterial infections
• Use of antibiotics in COPD
• Treatment of patients who develop respiratory failure

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on July 31, 2012
• Reviewed on January 23, 2022

Financial Disclosures

• Prof. Antonio Anzueto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.