Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Oxidants and antioxidant balance in the lungs
3. Oxidants and antioxidants in the lungs
4. Oxidative stress in COPD overview (1)
5. Measurements of oxidative stress
6. Synthesis of nitric oxide (NO)
7. Nitrosative stress in COPD
8. Mechanisms of membrane lipid peroxidation
9. 4-hydroxy-2-nonenal-adducts in COPD
10. Does oxidative stress occur in COPD?
11. Smoke induced emphysema in Nrf2 KO mice
12. Decline in NRF2-regulated antioxidants in COPD
13. Nrf2 and oxidative stress relationship in COPD
14. Regulation of NRF2 in COPD patients
15. NRF2 targeting with CDDO
16. What are the consequences of OS in COPD?
17. Model of histone acetylation and deacetylation
18. Effect of smoking and COPD on HDAC2
19. Nitration and HDAC2 activity
20. Smoke induced oxidative stress effects
21. Emphysema: apoptosis
22. Apoptosis and VEGF in emphysematous lungs
23. Apoptosis and oxidative stress
24. Decreased proteins in lungs of COPD patients
25. Molecular alterations in COPD lungs
26. Molecular alterations in COPD muscles
27. Protease / antiprotease
28. NRF2 way of protection against emphysema
29. NAC attenuates elastase-induced emphysema
30. Accelerated aging
31. Free radical theory of aging or senescence
32. Accelerated aging in COPD
33. SIRT-1 is decreased in the lungs in COPD
34. SMP-30 and age-associated deterioration
35. Effects of decreased SIRT1
36. Pathogenic triad of COPD
37. Mucus hypersecretion
38. Oxidants and mucin production
39. Airway remodelling
40. A link between oxidative injury and fibrosclerosis
41. Immune modulation
42. The nature of small-airway obstruction in COPD
43. HO1 prevents smoke induced B-cell infiltrates
44. Oxidative stress role in auto-immune response
45. Oxidative stress in COPD: summary

Topics Covered

• The involvement of oxidative stress in the pathogenic mechanisms of COPD
• Downregulation of antioxidant defenses
• Enhanced inflammation
• Apoptosis
• Protease/antiprotease imbalance
• Accelerated aging
• Immunemodulation
• Potential for targeted therapy

Links

Series:

• Advances in Chronic Obstructive Pulmonary Disease (COPD)

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on July 31, 2012
• Archived on February 25, 2021

Financial Disclosures

• Prof. William MacNee has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.