Gene structure, expression and regulation: DNA structure and replication
37 min
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- Stem Cells
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34 min
1. Stem cells: immortality or a healthy old age?- Dr. Jim McWhir
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40 min
2. Mouse embryonic stem cells- Prof. Sir Martin Evans
- Regenerative Medicine (I)
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26 min
3. Stem cells and regenerative medicine- Prof. Dame Julia Polak
- Dr. Anne Bishop
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27 min
4. Tissue engineering: the science, the technology and the industry- Prof. Robert Nerem
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41 min
5. Clinical potential of stem cells- Prof. John Martin
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11 min
6. Genes and cells therapy- Prof. Nagy Habib
- Regenerative Medicine (II)
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39 min
7. Stem cell therapy for the treatment of heart failure- Dr. James Willerson
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35 min
8. Vascular tissue engineering- Prof. Robert Nerem
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43 min
9. Stem cell biology and neurodegenerative diseases- Dr. Ronald McKay
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17 min
10. Cartilage stem cells: tools for joint repair?- Prof. Charles Archer
- Biotechnology
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46 min
11. Stem cell bioprocessing- Dr. Sakis Mantalaris
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68 min
12. Nanotechnology for tissue engineering- Prof. Thomas J. Webster
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37 min
13. Materials for tissue engineering- Dr. Molly Stevens
- Mr. Julian George
- Commercialization
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36 min
14. Commercialisation of stem cells- Dr. Gareth Roberts
- Ethical and Regulatory Considerations
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44 min
15. Stem cell ethics- Prof. Dame Anne McLaren
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23 min
16. The human fertilisation and embryology authority- Dame Suzi Leather
- Archived Lectures *These may not cover the latest advances in the field
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40 min
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture topics
- Stem cell - definition
- Stem cell - asymmetric and symmetric division
- Stem cell - clonogenicity
- Stem cells - embryonic or adult
- What's an embryonic stem cell
- ES cells - derivation of genetically modified mice
- ES cells develop normally after reintroduction
- What's an adult stem cell
- The difference between adult stem cells and ES
- Extrinsic and intrinsic renewal factors - mouse ES
- Extrinsic and intrinsic renewal factors - human ES
- What's immortality
- The bus theory
- Stem cells are potentially immortal and dangerous
- Why is immortality dangerous
- Why does an immortal organism die
- Non-immortal organism
- Normal cells have a restricted capacity to divide
- How is programmed cell death advantageous
- First strategy for generating an organism
- Second strategy for generating an organism
- The difference between the two strategies
- Being mortal protects from cancer
- Other causes for cellular death
- Apoptosis
- Apoptosis - extrinsic and intrinsic pathways
- Telomere shortening (1)
- Telomeres are the ends of chromosomes
- Telomeres - T loops
- DNA replication
- Telomere shortening (2)
- Stem cells overcome telomere shortening
- TERT expression reverses senescence
- The impact of regenerative medicine
- Regenerative medicine - perspectives
- Ways that regenerative medicine can affect us
- Adult stem cells in clinical trials
- Regenerative medicine can raise the lifespan
- Hurdles of ES-derived regenerative medicine
- Efficacy of regenerative medicine - studies
- Immune rejection
- Safety - tumorigenicity
- Safety - teratomas
- Additional safety provided by cell engineering
- Regulatory acceptance
- Conclusion
Topics Covered
- What is a stem cell?
- Properties of stem cells
- Adult and embryonic stem cells
- What is immortality?
- Why do we die?
- Mechanisms of programmed cell death
- Mutation
- Connection between tumour protection and ageing
- Impact of regenerative medicine
- Impact of stem cells on lifespan
- Average and maximum lifespan
Talk Citation
McWhir, J. (2009, August 25). Stem cells: immortality or a healthy old age? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/BCGB5009.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jim McWhir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
