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1. Introduction
2. Spinal Cord Injury (SCI) types
3. Quadriplegia (1)
4. Quadriplegia (2)
5. Outcomes after spinal cord injury
6. SCI epidemiology
7. Functional levels of SCI
8. American spinal injury association (ASIA) scale
9. Life expectancy after spinal cord injury
10. Most SCIs don't involve spinal cord transection
11. SCI in elderly individuals
12. Cervical spinal cord injuries - MRI
13. Central hemorrhagic necrosis
14. Pathophysiology of acute spinal cord injury
15. Post-traumatic spinal cord degeneration
16. Spinal cord injury and functional impairment (1)
17. Analysis of myelinated axons by line-sampling
18. Determinants of functional recovery (1)
19. Acute contusion spinal cord injury
20. Models for experimental SCI employed at UK
21. PSI (infinite horizon) impactor - developed at UK
22. Tissue dynamics over time post injury
23. Histological features of spinal cords with injuries
24. Secondary injury cascade
25. Glutamate release, Ca2+ and reactive oxygen (1)
26. Secondary injury - glutamate excitotoxicity
27. Role of glutamate in SCI (1)
28. Dose-dependent reduction of tissue loss
29. Role of glutamate in SCI (2)
30. Secondary injury - intracellular calcium overload
31. Injured cat spinal cord
32. Secondary injury - phospholipase A2 activation
33. Arachidonic acid release in white matter
34. Cyclooxygenase-generated eicosanoids
35. Sustained eicosanoid elevation in the spinal cord
36. Free radical-induced oxidative damage
37. Consequences of lipid peroxidative damage
38. Oxygen free radical-induced oxidative damage
39. Lipid peroxidative depletion of vitamin E
40. Time course of 4-HNE accumulation
41. Peroxynitrite and iron-dependent fenton chemistry
42. Fingerprints of cellular damage
43. Peroxynitrite role in acute SCI oxidative damage
44. Exacerbation of calcium overload (1)
45. Mitochondrial dysfunction
46. Time course of mitochondrial dysfunction
47. Post-traumatic lactic acidosis in the spinal cord
48. Post-traumatic decrease in ATP and PCr
49. Microvascular damage
50. Spinal cord vasculature
51. Relationship of post-traumatic SCBF
52. Intensive pretreatment with Vit. E & Se2+
53. Vitamin E pretreatment enhances recovery
54. Calcium, calpain and proteolytic damage
55. Glutamate release, Ca2+ and reactive oxygen (2)
56. Exacerbation of calcium overload (2)
57. Calpain over-activation following CNS injury
58. Time course of calpain activation
59. Calpain-mediated cytoskeletal degradation
60. Oligodendroglial apoptosis following SCI
61. Caspase-3 activation in oligodendroglia in SCI
62. Time course of post-traumatic inflammation
63. Methylprednisolone sodium succinate
64. Intravenous glucocorticoid pretreatment
65. Methylprednisolone: neuroprotective mechanisms
66. Methylprednisolone sodium succinate dosing
67. Second national acute spinal cord injury study (1)
68. Second national acute spinal cord injury study (2)
69. Effect of methylprednisolone on motor function
70. Future pharmacological treatments for acute SCI
71. Spinal cord injury and functional impairment (2)
72. Determinants of functional recovery (2)
73. Post-traumatic 'regenerative failure' in CNS
74. Promoting recovery of function after SCI (1)
75. Promoting recovery of function after SCI (2)

Topics Covered

• Spinal Cord Injury
• Outcomes and epidemiology
• Prevalence of blunt cord injury vs. transection
• Primary vs. secondary injury
• Importance of axonal and myelin sparing
• Molecular mechanisms of secondary injury
• Success with antioxidant therapies
• Future neuroprotective vs. neurorestorative treatments

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 11, 2012

Financial Disclosures

• Prof. Edward D. Hall has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.