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- Basic Concepts
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1. Molecular structure of the human genome
- Prof. Jonathan Wolfe
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2. Introduction to mutation and disease
- Prof. Jonathan Wolfe
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3. Introduction to genetic diseases
- Prof. Jonathan Wolfe
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4. Historical introduction to human diversity I
- Prof. Dallas Swallow
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5. Historical introduction to human diversity II
- Prof. Dallas Swallow
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6. Introduction to cytogenetics 1
- Dr. Sioban SenGupta
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7. Introduction to cytogenetics 2
- Dr. Sioban SenGupta
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8. Introduction to cytogenetics 3
- Dr. Sioban SenGupta
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9. The Y-chromosome
- Prof. Mark Jobling
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10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases
- Prof. Immo Scheffler
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11. Mechanisms of DNA repair by recombination
- Prof. James Haber
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12. Techniques utilized in molecular genetics
- Dr. Cecil Lewis
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13. Genome mapping
- Dr. Simon Gregory
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14. Copy number variation
- Dr. Ömer Gökçümen
- Genetics and Disease
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15. Genetic association studies
- Prof. David Balding
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16. Quantitative genetics and multifactorial inheritance
- Dr. Lara Bauman
- Human Evolutionary Genetics
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17. Population genetics
- Dr. Murray P. Cox
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18. Inference on human history through DNA
- Prof. Guido Barbujani
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19. Human adaptation
- Prof. Rasmus Nielsen
- Specialized Topics
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20. Accessing and using ENCODE data
- Prof. Peggy Farnham
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21. Pharmacogenetics
- Prof. Ann Daly
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22. Genetics in forensics
- Dr. Angel Carracedo
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23. The development and evolution of human gene therapy
- Prof. Theodore Friedmann
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24. Next generation sequencing technologies
- Dr. Krishna Veeramah
Printable Handouts
Navigable Slide Index
- Introduction
- Genetics influence traits
- What is a quantitative trait?
- Quantitative and multifactorial inheritance
- Some history
- Some more history
- Basic biometric model (1)
- Basic biometric model (2)
- Basic biometric model (3)
- Identity states
- Identity coefficients
- Kinship coefficients
- Covariances for relatives (1)
- Covariances for relatives (2)
- Polygenic model (1)
- Polygenic model (2)
- Add environment
- Modeling environment/error
- Household effects models
- Variance component models
- Statistical process
- A gene x environment model
- Why? how?
- G x E model, mean
- G x E model, variance
- The San Antonio family heart study
- The data
- The questions
- The results, mean
- Gene ontology analysis
- The results, heritability
- GO BP results poly G x S
- GO-BP graph for sig poly G x S
- QTL mapping uses genotype data
- Genotyping
- QTL mapping
- Multivariate model
- SAFADS example
- Insulin Resistance Syndrome (IRS)
- Four trait heritability analysis
- QTL mapping process (1)
- QTL mapping process (2)
- FSI, BMI, leptin and DBP (1)
- FSI, BMI, leptin and DBP (2)
- Thanks
- References
Topics Covered
- Basic Biometric Model: single locus model, identity states and coefficients, Covariances for relatives, polygenic model
- Modeling environment/error
- Gene by environment interaction model and example
- QTL mapping model
- Multivariate model and example
Talk Citation
Bauman, L. (2012, May 22). Quantitative genetics and multifactorial inheritance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/RSBU3329.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Lara Bauman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.