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1. Introduction
2. Antigenic challenge in intestine
3. Prevention of intestinal inflammation (1)
4. Prevention of intestinal inflammation (2)
5. Intestinal macrophages
6. Resting colonic F4/80+ cells activated phenotype
7. No proinflammatory cytokines in F4/80+ cells
8. All that is F4/80+ is not a macrophage
9. CX3CR1 defines colonic macrophage subsets
10. CX3CR1 defines colonic macrophage functions
11. Colonic macrophages in inflammation
12. Phenotypic comparison of mouse macrophages
13. Macrophage differentiation: context dependent (1)
14. Intestinal macrophage differentiation in situ? (1)
15. Intestinal macrophage differentiation in situ? (2)
16. Intestinal macrophage differentiation in situ? (3)
17. Monocyte origin of resident colonic macrophages
18. Ly6C-hi monocytes in steady state colon
19. Control of colonic macrophage development
20. CD200R1 does not regulate colonic macrophages
21. IL10 & regulation of resident colonic macrophages
22. Macrophage differentiation: context dependent (2)
23. Macrophages and inflammatory bowel disease
24. TNFalpha & macrophages in acute colitis
25. Colonic macrophage subsets in inflammation
26. Cytokine production by macrophages in colitis
27. Generation of macrophages in colitis
28. Intestinal macrophage subsets in mice
29. Intestinal macrophage subsets in humans
30. Intestinal macrophages in health and disease
31. Intestinal macrophages in regulatory T cell function
32. Acknowledgments

Topics Covered

• Macrophages play essential roles in both homeostasis and inflammation in the intestine
• Distinct populations of macrophages control each of these functions
• Novel strategies for characterizing mouse intestinal macrophages
• A single population of monocyte gives rise to both resident and inflammatory macrophages in intestine
• Actions of macrophages in healthy intestine in mice
• Actions of macrophages in inflamed intestine in mice
• Similar processes in humans
• Application of knowledge of macrophages to human diseases including Crohn's disease

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Mowat, A. (2012, August 28). Intestinal macrophages - heterogeneity, origins and functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 3, 2023, from https://hstalks.com/bs/2308/.
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Publication History

• Published on August 28, 2012

Financial Disclosures

• Prof. Allan Mowat has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.