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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Inflammation caused by innate immunity
3. Pleiotropic function of macrophages
4. The concept of the macrophage subtypes (1)
5. Toll-like receptors and their ligands
6. Signaling pathway for IL-1/TLR family
7. Post-transcriptional regulation
8. Epigenetic regulation by histone modification
9. Histone lysine methylation
10. LPS (TLR4) stimulation
11. Jmjd3 expression in response to LPS
12. Jmjd3 family
13. Generation of Jmjd3 knockout mice
14. Jmjd3-/- mice neonatal death
15. Jmjd3 and macrophages elicited by thioglycollate
16. Jmjd3 and recruitment of macrophages to Listeria
17. The concept of the macrophage subtypes (2)
18. Chitin as an inducer of M2 macrophages
19. Jmjd3 is critical for MR expression
20. Jmjd3 role in M2 macrophage polarization
21. Jmjd3 is critical for eosinophils recruitment
22. Nippostrongylus brasiliensis infection model
23. Impaired M2 macrophage marker expression
24. Jmjd3 recruits eosinophils against NB infection
25. Jmjd3 is critical for inducing Th2 response
26. GM-CSF and M-CSF
27. M-CSF M2 macrophage marker expression
28. M2 macrophage marker expression
29. Identification of trimethylated H3K27 (me3) loci
30. H3K27me3 and gene expression correlation in WT
31. H3K27me3 peak in Jmjd3-/- macrophages
32. IRF4, one of the targets of Jmjd3 for demethylation
33. Jmjd3 demethylase activity and IRF4 induction
34. IRF4 importance to chitin administration in vivo
35. M2 expression in IRF4-/- M-CSF-induced-BMM
36. Retroviral expression of IRF4
37. Conclusion
38. Control of M2 macrophage differentiation
39. Macrophage differentiation, chromatin remodeling
40. Acknowledgements

Topics Covered

• The innate immune cells
• Pathogen sensing receptor system
• Histone modifications and inflammation control
• Critical role of Jmjd3, a trimethyl H3K27 specific demethylase, in M2 macrophage differentiation
• Identification of IRF4 as a Jmjd3 target gene inducing M2 macrophages

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Dr. Osamu Takeuchi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.