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1. Introduction
2. Inflammation caused by innate immunity
3. Pleiotropic function of macrophages
4. The concept of the macrophage subtypes (1)
5. Toll-like receptors and their ligands
6. Signaling pathway for IL-1/TLR family
7. Post-transcriptional regulation
8. Epigenetic regulation by histone modification
9. Histone lysine methylation
10. LPS (TLR4) stimulation
11. Jmjd3 expression in response to LPS
12. Jmjd3 family
13. Generation of Jmjd3 knockout mice
14. Jmjd3-/- mice neonatal death
15. Jmjd3 and macrophages elicited by thioglycollate
16. Jmjd3 and recruitment of macrophages to Listeria
17. The concept of the macrophage subtypes (2)
18. Chitin as an inducer of M2 macrophages
19. Jmjd3 is critical for MR expression
20. Jmjd3 role in M2 macrophage polarization
21. Jmjd3 is critical for eosinophils recruitment
22. Nippostrongylus brasiliensis infection model
23. Impaired M2 macrophage marker expression
24. Jmjd3 recruits eosinophils against NB infection
25. Jmjd3 is critical for inducing Th2 response
26. GM-CSF and M-CSF
27. M-CSF M2 macrophage marker expression
28. M2 macrophage marker expression
29. Identification of trimethylated H3K27 (me3) loci
30. H3K27me3 and gene expression correlation in WT
31. H3K27me3 peak in Jmjd3-/- macrophages
32. IRF4, one of the targets of Jmjd3 for demethylation
33. Jmjd3 demethylase activity and IRF4 induction
34. IRF4 importance to chitin administration in vivo
35. M2 expression in IRF4-/- M-CSF-induced-BMM
36. Retroviral expression of IRF4
37. Conclusion
38. Control of M2 macrophage differentiation
39. Macrophage differentiation, chromatin remodeling
40. Acknowledgements

Topics Covered

• The innate immune cells
• Pathogen sensing receptor system
• Histone modifications and inflammation control
• Critical role of Jmjd3, a trimethyl H3K27 specific demethylase, in M2 macrophage differentiation
• Identification of IRF4 as a Jmjd3 target gene inducing M2 macrophages

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Dr. Osamu Takeuchi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.