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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Intro slide
- What is ubiquitin?
- The ubiquitin proteasome system (UPS)
- Nobel Prize for ubiquitin
- Slices of normal brain and Alzheimer brain
- The ubiquitin pathway & neurodegenerative disease
- Cortical Lewy body contain ubiquitylated proteins
- Ubiquitylated proteins in Lewy neurites
- Dementia with Lewy bodies
- Ubiquitylated proteins in Alzheimer's disease
- Dystrophic neurites contain ubiquitylated proteins
- Protein degradation is crucial for synaptic functions
- Mutations in PARKIN cause juvenile PD
- The UPS and the ageing brain
- Gene expression response to protein aggregates
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 5
- Expression of MEK5 in aggregate producing cells
- Mitogen activated protein kinase pathways
- p62/MEK5/ERK5 and Alzheimer's disease
- p62/MEK5/ERK5 and dementia with Lewy bodies
- p62/MEK5/ERK5 and granulovacuolar degeneration
- Model: neurofibrillary tangles & p62/MEK5/ERK5
- Model: Lewy bodies & p62/MEK5/ERK5
- p62-MEK5-ERK5-MEF2 & neurodegeneration
- The UPS & neurodegeneration
- Clinical implications of the findings
Topics Covered
- Alzheimer's disease and dementia with Lewy bodies
- Ubiquitin and the ubiquitin pathway of intracellular proteolysis
- Ubiquitin immunocytochemistry in understanding chronic neurodegenerative disease
- Ubiquitin and the discovery of dementia with Lewy bodies
- Importance of ubiquitin for normal brain functions
- Ubiquitin and Parkinson's disease
- Intraneuronal protein aggregation and neurodegenerative disease
- Experimental demonstration of generic gene expression changes in response to protein aggregates
- Expression of the mitogen activated protein kinase (MEK5)
- ERK5 kinase module in Alzheimer's disease and dementia with Lewy bodies
- Ubiquitin-p62-MEK5/ERK5 pathway of neuronal survival in Alzheimer related disorders
- Diagnostic and therapeutic importance of ubiquitin/kinase mediated neuronal survival and anti-apoptotic pathways
Links
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Talk Citation
Mayer, J. (2007, October 1). Ubiquitination and Alzheimer related disorders [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/OYWE5038.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Mayer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Ubiquitination and Alzheimer related disorders
Published on October 1, 2007
12 min