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- Overview of Chaperone Networks
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1. Mapping the molecular chaperone interaction network in yeast
- Prof. Walid A. Houry
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2. The interaction network of the GroEL chaperonin
- Prof. Dr. F. Ulrich Hartl
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3. Human heat shock protein families
- Prof. Herman Kampinga
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4. Extracellular proteostasis: an emerging field
- Prof. Mark Wilson
- Proteasome Networks
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6. Biogenesis of the eukaryotic proteasome
- Prof. Mark Hochstrasser
- Understanding Intrinsically Disordered Proteins in Protein Homeostasis
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7. Intrinsically unstructured proteins: regulation and disease
- Dr. M. Madan Babu
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8. The roles of intrinsic disorder in protein interaction networks
- Prof. Vladimir N. Uversky
- Gene Regulatory Networks and their Role in Protein Homeostasis
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10. Structure, evolution and dynamics of gene regulatory networks
- Dr. M. Madan Babu
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12. Protein-protein interaction networks
- Prof. Peter Csermely
- Protein Homeostasis in the Endoplasmic Reticulum
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13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum
- Prof. David B. Williams
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14. The unfolded protein response
- Prof. Kazutoshi Mori
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15. Role of ER stress in cystic fibrosis airway inflammation
- Dr. Carla Maria Pedrosa Ribeiro
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16. The recognition of misfolded glycoproteins in the endoplasmic reticulum
- Dr. David Y. Thomas
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17. Chaperone systems of the endoplasmic reticulum
- Prof. Linda M. Hendershot
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18. The ERAD network
- Prof. Daniel Hebert
- Protein Homeostasis in the Mitochondria
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19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases
- Dr. David A. Dougan
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21. Mitochondrial chaperonin Hsp60: locations, functions and pathology
- Prof. Francesco Cappello
- Prof. Alberto J. L. Macario
- Protein Homeostasis in the Nucleus
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22. Nuclear protein quality control degradation
- Dr. Richard G. Gardner
- Protein Homeostasis in Aging Disease
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23. Protein homeostasis during ageing: C. elegans as a model organism
- Prof. Nektarios Tavernarakis
- Protein Homeostasis in Neurodegeneration
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24. Endoplasmic reticulum stress in neurodegenerative diseases
- Prof. Claudio Soto
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25. Roles for Hsp40 molecular chaperones in protein misfolding disease
- Prof. Douglas M. Cyr
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26. Protein folding in vivo
- Prof. James Bardwell
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27. Protein degradation and defense against neurodegenerative disease 1
- Prof. Alfred Goldberg
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28. Protein degradation and defense against neurodegenerative disease 2
- Prof. Alfred Goldberg
Printable Handouts
Navigable Slide Index
- Introduction
- Outcomes of misfolded protein aggregation
- The study of neurodegenerative diseases
- Regulation of Hsp70 function by Hsp40
- Domain structure of Hsp40 family members
- Functional specificity of Type I and Type II HSP40
- Hsp70 and Hsp40s act via opposing mechanisms
- Hsp40s differentially modulate fibril formation
- RNQ+ as a model system for amyloid assembly
- Rnq1 forms self-perpetuating aggregates
- Hsp40 types - opposing roles on RNQ+ assembly
- Sis1 and Ydj1 recognize different regions of Rnq1
- Hsp40 types bind different regions of Rnq1 prions
- Rnq1 elevation kills yeast containing RNQ+ prions
- Overexpression of Sis1 suppresses Rnq1 toxicity
- A possible mechanism for Rnq1 toxicity?
- Sis1 decreases unassembled Rnq1 pool
- Sis1 promotes RNQ prion accumulation
- RNQ prion accumulation may help reduce toxicity
- How type I Hsp40s suppress amyloid formation
- Rnq1 prion domain overexpression in yeast
- Ydj1 required for tolerance of PrD overexpression
- Ydj1 overexpression inhibits PrD aggregation
- PrD accumulation in the absence of Ydj1
- A model for PRD prion formation
- Hsp40s suppress proteotoxicity in different ways
- Acknowledgements
Topics Covered
- Protein aggregation in conformational disease
- The Hsp40 system
- The Hsp70 system
- Small oligomers, prion, yeast, Huntington's disease and protein triage
- Mechanisms for proteotoxicity
- Mechanisms for amyloid disease
Links
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Talk Citation
Cyr, D.M. (2012, February 20). Roles for Hsp40 molecular chaperones in protein misfolding disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/GMGJ2525.Export Citation (RIS)
Publication History
- Published on February 20, 2012
Financial Disclosures
- Prof. Douglas M. Cyr has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.