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1. Introduction
2. Scope
3. Contents
4. The chaperoning system, the chaperonopathies
5. Molecular chaperones/Hsps: cell life and survival
6. Disruption of Hsp function = Chaperonopathies
7. The chaperonopathies
8. Hsp60: structure, location, function
9. Human Hsp60 amino acid sequence
10. The chaperonin Hsp60
11. Hsp60 assists protein folding in mitochondria
12. Hsp60 resides and works inside mitochondria
13. Hsp60 in cells: light microscopy and EM
14. Hsp60: genetic chaperonopathies
15. Hsp60 gene, protein and mutations
16. Hsp60 and cancer
17. Hsp60 in carcinogenesis of four tissues/organs
18. Uterine exocervix
19. Carcinogenic steps in uterine exocervix
20. Hsp60 increases in exocervical carcinogenesis
21. Large bowel
22. Carcinogenic steps in large bowel
23. Hsp60 increases in large bowel carcinogenesis
24. Hsp60 immunopositivity detects dysplastic cells
25. Hsp60 in neural and vasal infiltration in cancer
26. Prostate
27. Carcinogenic steps in prostate
28. Hsp60 increases during prostate carcinogenesis
29. Hsp60 in distant metastasis of prostate cancer
30. Airways
31. Carcinogenic steps of airways
32. Hsp60 decrease during airways carcinogenesis
33. Hsp60 can increase or decrease in carcinogenesis
34. Studies showed increase, decrease or no change
35. Examples of Hsp60 levels in tumors (1)
36. Examples of Hsp60 levels in tumors (2)
37. Hsp60 levels in tumors predicting prognosis
38. Hsp60 secretion by cancer cells
39. Hsp60 present in exosomes from cancer cells
40. Inhibitors confirmed Hsp60 secretion
41. Experiments with secretion inhibitors
42. Conclusions and perspectives (1)
43. Conclusions and perspectives (2)
44. Conclusions and perspectives (3)
45. Conclusions and perspectives (4)
46. Conclusions and perspectives (5)
47. Bibliography (1)
48. Bibliography (2)

Topics Covered

• Chaperonology: the study of molecular chaperones in all their aspects, normal and pathological. The chaperoning system: the entire complement of chaperones in an organism, including co-chaperones and co-factors. Chaperonopathies: diseases in which abnormal chaperones play a pathogenic role. Hsp60: the mitochondrial chaperonin Cpn60. Genetic Hsp60 chaperonopathies: pathologic conditions in which Hsp60 mutations are involved as etiologic-pathogenic factors. Hsp60 in cancer: Hsp60 chaperonopathies by mistake, in which the chaperonin helps the tumour rather than the patient

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Oncology

Talk Citation

Cappello, F. and Macario, A. (2012, February 20). Mitochondrial chaperonin Hsp60: locations, functions and pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 29, 2020, from https://hstalks.com/bs/2231/.

Publication History

• Published on February 20, 2012

Financial Disclosures

• Dr. Francesco Cappello has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Alberto Macario has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.