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Printable Handouts
Navigable Slide Index
- Introduction
- Scope
- Contents
- The chaperoning system, the chaperonopathies
- Molecular chaperones/Hsps: cell life and survival
- Disruption of Hsp function = Chaperonopathies
- The chaperonopathies
- Hsp60: structure, location, function
- Human Hsp60 amino acid sequence
- The chaperonin Hsp60
- Hsp60 assists protein folding in mitochondria
- Hsp60 resides and works inside mitochondria
- Hsp60 in cells: light microscopy and EM
- Hsp60: genetic chaperonopathies
- Hsp60 gene, protein and mutations
- Hsp60 and cancer
- Hsp60 in carcinogenesis of four tissues/organs
- Uterine exocervix
- Carcinogenic steps in uterine exocervix
- Hsp60 increases in exocervical carcinogenesis
- Large bowel
- Carcinogenic steps in large bowel
- Hsp60 increases in large bowel carcinogenesis
- Hsp60 immunopositivity detects dysplastic cells
- Hsp60 in neural and vasal infiltration in cancer
- Prostate
- Carcinogenic steps in prostate
- Hsp60 increases during prostate carcinogenesis
- Hsp60 in distant metastasis of prostate cancer
- Airways
- Carcinogenic steps of airways
- Hsp60 decrease during airways carcinogenesis
- Hsp60 can increase or decrease in carcinogenesis
- Studies showed increase, decrease or no change
- Examples of Hsp60 levels in tumors (1)
- Examples of Hsp60 levels in tumors (2)
- Hsp60 levels in tumors predicting prognosis
- Hsp60 secretion by cancer cells
- Hsp60 present in exosomes from cancer cells
- Inhibitors confirmed Hsp60 secretion
- Experiments with secretion inhibitors
- Conclusions and perspectives (1)
- Conclusions and perspectives (2)
- Conclusions and perspectives (3)
- Conclusions and perspectives (4)
- Conclusions and perspectives (5)
- Bibliography (1)
- Bibliography (2)
Topics Covered
- Chaperonology: the study of molecular chaperones in all their aspects, normal and pathological. The chaperoning system: the entire complement of chaperones in an organism, including co-chaperones and co-factors. Chaperonopathies: diseases in which abnormal chaperones play a pathogenic role. Hsp60: the mitochondrial chaperonin Cpn60. Genetic Hsp60 chaperonopathies: pathologic conditions in which Hsp60 mutations are involved as etiologic-pathogenic factors. Hsp60 in cancer: Hsp60 chaperonopathies by mistake, in which the chaperonin helps the tumour rather than the patient
Talk Citation
Cappello, F. and Macario, A. (2012, February 20). Mitochondrial chaperonin Hsp60: locations, functions and pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 24, 2021, from https://hstalks.com/bs/2231/.Publication History
Financial Disclosures
- Dr. Francesco Cappello has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Alberto Macario has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Mitochondrial chaperonin Hsp60: locations, functions and pathology
Published on February 20, 2012
26 min