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The topic of this talk belongs to chaperonology,
the scientific discipline dealing with molecular chaperones,
normal and abnormal in physiology and pathology.
The subfield of chaperonology encompasses chaperonopathies,
the diseases in which chaperones play a role in pathogenesis and/or are
biomarkers useful for diagnosis and assessing prognosis and response to treatment.
This talk focuses on one among the many chaperones; HSP60,
traditionally known as in mitochondrial chaperonin, CPN 60,
that as the name suggests,
has a molecular weight of about 60 kiloDalton.
HSP60 plays a variety of roles inside and outside cells,
including not only improving quality control, folding,
refolding, translocation degradation, but also in other functions more or
less unrelated to its task of assisting polypeptide maturation.
Furthermore, HSP60 is associated with many pathological processes.
Because of this and because its
chaperonin can occur in any cellular or extracellular compartment,
its malfunction can be predicted to have wider spread and probably serious consequences.
It is impossible to cover all aspects of HSP60 physiology and pathology in one talk,
therefore, in this talk,
we have concentrated on some aspects of
genetic HSP60 chaperonopathies and on work pertaining to HSP60 and cancer.