• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Cystic fibrosis
3. CF airways disease
4. Ca levels in CF human airway epithelia cultures
5. Ca mobilization in airway epithelia cells
6. Apical GPCR activation and Ca signaling
7. Apical ER/Ca store expansion
8. Summary of earlier studies
9. Modeling the CF phenotype
10. Mucosal SMM promotes ER/Ca store expansion
11. Apical ER/Ca store expansion- Cl- secretion
12. Apical ER/Ca store expansion-hyperinflammation
13. SMM affects inflammatory mediator production
14. SMM affects metabolism and protein synthesis
15. Hypothesis: causes of ER/Ca store expansion
16. ER unfolded proteins activate UPR pathways
17. IRE1 pathway
18. Airway epithelial adaptive response hypothesis
19. SMM induces XBP-1 mRNA splicing
20. SMM induces ER protein chaperone expression
21. Increased XBP-1s, BIP and PDI in human CF HBE
22. XBP-1 mRNA splicing coupled to IL-8 secretion
23. The role of XBP-1 in ER/Ca2+ store expansion (1)
24. Spliced XBP-1 promotes ER Ca store expansion
25. The role of XBP-1 in ER/Ca2+ store expansion (2)
26. DN-XBP-1 inhibit ER Ca store expansion
27. The role of spliced XBP-1 in IL-8 secretion
28. IRE1 in airway epithelial hyperinflammation
29. IRE1 isoforms: IRE1alpha and IRE1beta
30. 16HBE14o- cells only express IRE1alpha
31. Studying ER Ca store expansion in vivo
32. XBP-1 splicing - ER expansion coupling
33. XBP-1 splicing is increased in inflamed airways
34. Future research directions
35. Summary
36. Acknowledgments

Topics Covered

• Pathophysiology: abnormal rheology of airway secretions
• Impaired mucociliary clearance
• Airway obstruction
• Persistent lung infections and inflammation
• Respiratory failure
• Progressive lung disease as the main cause of death
• Role of ER stress responses in CF airways inflammation
• Studies on the mechanism of ER stress activation-mediated airway cytokine secretion

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Dr. Carla Maria Pedrosa Ribeiro has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.