• Clinical Introduction
• 49 min
  1. Frontotemporal dementia

  • Prof. Bruce Miller
• 57 min
  2. Parkinson disease

  • Prof. Stanley Fahn
• 35 min
  3. Atypical parkinsonian syndromes

  • Dr. David Burn
• 40 min
  4. Huntington's disease

  • Prof. Roger Barker
• Neuroimaging
• 22 min
  5. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• Pathology, Genetic and Molecular Aspects (1)
• 42 min
  6. A molecular understanding of Alzheimer's disease

  • Prof. John Hardy
• 33 min
  7. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 52 min
  8. The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers

  • Dr. Michael Hutton
• 12 min
  9. Ubiquitination and Alzheimer related disorders

  • Prof. John Mayer
• Pathology, Genetic and Molecular Aspects (2)
• 46 min
  10. The molecular biology of Huntington's disease

  • Prof. David C. Rubinsztein
• 46 min
  11. Metals, oxidative stress and neurodegeneration

  • Prof. Ashley Bush
• Latest Developments in the Field
• 46 min
  12. Animal models of tauopathy

  • Prof. David Westaway
• 61 min
  13. Parkinson's disease and transplants

  • Prof. Roger Barker
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  14. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 36 min
  15. Motor neurone disease: molecular basis

  • Prof. Kevin Talbot
• 51 min
  16. Alzheimer's disease (AD)

  • Prof. John Hodges
• 53 min
  17. Frontotemporal dementia syndromes

  • Prof. John Hodges
• 38 min
  18. Motor neurone disease: clinical aspects

  • Prof. Kevin Talbot
• 26 min
  19. Neuro-imaging in dementia: using MRI in routine work-up

  • Prof. Philip Scheltens
• 53 min
  20. Prion diseases

  • Prof. Pierluigi Gambetti
• 38 min
  21. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 21 min
  22. Neurodegenerative disease: expression levels of normal sequence pathogenic proteins contribute to risk of disease

  • Prof. John Hardy
• 44 min
  23. Mutations in parkinsonian syndromes

  • Dr. Andrew Singleton
• 42 min
  24. Experimental therapies in Alzheimer's disease: the development and use of mouse models

  • Prof. David Westaway
• 32 min
  25. Frontotemporal dementia

  • Prof. Bruce Miller

Printable Handouts

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Navigable Slide Index

1. Intro slide
2. Outline of talk
3. Practice parameter - guidelines
4. Practice recommendation
5. Potentially reversible conditions
6. Potentially reversible primary aetiologies
7. The decreasing prevalence of reversible dementias
8. Treatable cause (?) - 1
9. Treatable cause (?) - 2
10. Reason for MRI in evaluation of dementia
11. "Treatable causes" with imaging
12. The 'exclusionary' approach to dementia
13. The 'inclusionary' approach
14. Changing indications for imaging
15. Basic MRI protocol
16. The spectrum of FTLD
17. The need to look at all slices
18. Subcortical vascular cognitive impairment
19. CADASIL
20. Specific type of vascular dementia
21. Thalamic lesions in vascular dementia
22. CJD: sporadic and variant
23. CBD
24. PSP
25. Medial temporal lobe (MTL) in AD
26. Alzheimer's Disease: Braak stages
27. Hippocampal volume
28. The 'fingerprint' of AD
29. MTL atrophy: visual rating
30. Visual rating of MTA
31. Visual rating of MTA - examples
32. Visual rating of MTA - reliability
33. Visually and volumetrically estimated MTA
34. Correlation with pathology
35. Assessment MTL atrophy - qualitative rating
36. Volumetry of MTA
37. Visual rating and volumetry of the MTL
38. Diagnostic value of MTA - AD vs. ND
39. Diagnostic value of MTA - AD vs. C
40. MTA assessment in routine practice
41. MTA on MRI in dementia with LB and VaD
42. Study results
43. Patterns of cerebral atrophy in dementia with LB
44. MRI volumetric study of dementia with LB
45. Temporal lobe on MRI in PD with dementia
46. Presenile/senile difference in hippocampal atrophy
47. Analysis using voxal based morphometry
48. MTA in MCI
49. MTA predicts AD in patients with MCI
50. MTA predicts dementia in patients with MCI
51. MTA visual score
52. Conclusions

Topics Covered

• Changing role of structural imaging in dementia
• Current diagnostic use
• Sensitivity and specificity
• Identifying biological markers for disease
• Examples from clinical practice

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Methods
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Philip Scheltens has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.