• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Cellular protein homeostasis
3. Proteases and chaperones
4. Plants are exposed to adverse environments
5. Arabidopsis thaliana: a model flowering plant
6. 26S proteasome structure
7. Proteasome 20S core particle
8. 19S regulatory particle structure
9. 19S regulatory particle function
10. Arabidopsis 26S proteasome subunits
11. Arabidopsis ubiquitination pathway
12. Pathways affected by Arabidopsis UPS pathway
13. Arabidopsis E3 ligase gene families
14. Regulation of UPS pathway in Arabidopsis
15. Hsp70 family chaperones in Arabidopsis
16. Hsp70 structure
17. Hsp70 functional cycle
18. Hsp70 functions in Arabidopsis
19. Arabidopsis Hsp70 interaction network
20. Hsp40/J-domain family structure
21. J-domain proteins in Arabidopsis
22. J-domain protein functions
23. J-domain protein ARC6 in plastid division
24. Function of ARC6 J-domain protein
25. Arabidopsis Hsp90 isoforms
26. Hsp90 structure
27. Hsp90 co-chaperones
28. Cytosolic Hsp90 functional cycle
29. Hsp90 interacts with SGT1 and RAR1
30. Interactions between HSP90, SGT1 and RAR1
31. AtHsp90s interaction network
32. Arabidopsis heat shock transcription factors (hstfs)
33. Tissue specific expression of hstfs
34. Heat shock factor interaction network
35. Small heat shock proteins
36. Arabidopsis small heat shock proteins
37. Predicted potential sHSP interactors
38. Potential Arabidopsis chaperone interactions
39. Thanks

Topics Covered

• Plant cellular protein quality control systems
• Arabidopsis regulated protein degradation by the proteasome
• Plant stress resistance
• Mechanism of action of molecular chaperones
• Molecular chaperones in Arabidopsis
• Chaperone interaction networks in Arabidopsis

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology
• Plant & Animal Sciences

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Prof. Rongmin Zhao has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.