• Clinical Introduction
• 49 min
  1. Frontotemporal dementia

  • Prof. Bruce Miller
• 57 min
  2. Parkinson disease

  • Prof. Stanley Fahn
• 35 min
  3. Atypical parkinsonian syndromes

  • Dr. David Burn
• 40 min
  4. Huntington's disease

  • Prof. Roger Barker
• Neuroimaging
• 22 min
  5. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• Pathology, Genetic and Molecular Aspects (1)
• 42 min
  6. A molecular understanding of Alzheimer's disease

  • Prof. John Hardy
• 33 min
  7. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 52 min
  8. The role of MAPT (Tau) in neurodegenerative disease: one bullet with many triggers

  • Dr. Michael Hutton
• 12 min
  9. Ubiquitination and Alzheimer related disorders

  • Prof. John Mayer
• Pathology, Genetic and Molecular Aspects (2)
• 46 min
  10. The molecular biology of Huntington's disease

  • Prof. David C. Rubinsztein
• 46 min
  11. Metals, oxidative stress and neurodegeneration

  • Prof. Ashley Bush
• Latest Developments in the Field
• 46 min
  12. Animal models of tauopathy

  • Prof. David Westaway
• 61 min
  13. Parkinson's disease and transplants

  • Prof. Roger Barker
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  14. Neuropathology of neurodegenerative disorders

  • Prof. Jillian Kril
• 36 min
  15. Motor neurone disease: molecular basis

  • Prof. Kevin Talbot
• 51 min
  16. Alzheimer's disease (AD)

  • Prof. John Hodges
• 53 min
  17. Frontotemporal dementia syndromes

  • Prof. John Hodges
• 38 min
  18. Motor neurone disease: clinical aspects

  • Prof. Kevin Talbot
• 26 min
  19. Neuro-imaging in dementia: using MRI in routine work-up

  • Prof. Philip Scheltens
• 53 min
  20. Prion diseases

  • Prof. Pierluigi Gambetti
• 38 min
  21. Mitochondrial disorders and neurodegeneration

  • Prof. Anthony Schapira
• 21 min
  22. Neurodegenerative disease: expression levels of normal sequence pathogenic proteins contribute to risk of disease

  • Prof. John Hardy
• 44 min
  23. Mutations in parkinsonian syndromes

  • Dr. Andrew Singleton
• 42 min
  24. Experimental therapies in Alzheimer's disease: the development and use of mouse models

  • Prof. David Westaway
• 32 min
  25. Frontotemporal dementia

  • Prof. Bruce Miller

Printable Handouts

PDF

Navigable Slide Index

1. Intro slide
2. Motor neurone diseases
3. MND: a neurodegenerative disease
4. Definition
5. Synonyms
6. Epidemiology
7. Age of onset
8. ALS: spinal onset
9. Relevant investigations
10. ALS: bulbar onset
11. Relevant investigations
12. Progressive Muscular Atrophy
13. Primary Lateral Sclerosis
14. Regional variants
15. Diagnosis
16. El-Escorial Criteria
17. Clinical utility of El-Escorial criteria
18. Conveying the diagnosis
19. Clinical progression
20. Natural history of MND/ALS
21. Prognostic guides
22. One disease or many?
23. Molecular neuropathology: Bunina bodies
24. Molecular neuropathology: skein-like inclusions
25. Hyaline inclusions
26. Dystrophic neurites
27. Familial ALS/MND
28. SOD1 associated ALS/MND
29. Clinical follow up
30. The Care Team
31. Drugs treatments
32. Evidence for clinical benefit with riluzole
33. Human therapeutic trials
34. Treatable symptoms
35. Enablement
36. Weight loss
37. Nutritional management
38. Assessment of respiratory function
39. Respiratory care
40. ALS as a multisystem disease
41. Cognitive impairment
42. Neuropathology of MND dementia
43. Key points
44. The future

Topics Covered

• Main clinical subtypes of MND
• Neuropathological features
• Molecular pathology and prognosis
• Multidisciplinary management
• Effectiveness of current drug treatments

Links

Series:

• Neurodegenerative Diseases

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Kevin Talbot has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.