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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Intro slide
- Motor neurone diseases
- MND: a neurodegenerative disease
- Definition
- Synonyms
- Epidemiology
- Age of onset
- ALS: spinal onset
- Relevant investigations
- ALS: bulbar onset
- Relevant investigations
- Progressive Muscular Atrophy
- Primary Lateral Sclerosis
- Regional variants
- Diagnosis
- El-Escorial Criteria
- Clinical utility of El-Escorial criteria
- Conveying the diagnosis
- Clinical progression
- Natural history of MND/ALS
- Prognostic guides
- One disease or many?
- Molecular neuropathology: Bunina bodies
- Molecular neuropathology: skein-like inclusions
- Hyaline inclusions
- Dystrophic neurites
- Familial ALS/MND
- SOD1 associated ALS/MND
- Clinical follow up
- The Care Team
- Drugs treatments
- Evidence for clinical benefit with riluzole
- Human therapeutic trials
- Treatable symptoms
- Enablement
- Weight loss
- Nutritional management
- Assessment of respiratory function
- Respiratory care
- ALS as a multisystem disease
- Cognitive impairment
- Neuropathology of MND dementia
- Key points
- The future
Topics Covered
- Main clinical subtypes of MND
- Neuropathological features
- Molecular pathology and prognosis
- Multidisciplinary management
- Effectiveness of current drug treatments
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Talbot, K. (2007, October 1). Motor neurone disease: clinical aspects [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/ILZH6528.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Kevin Talbot has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.