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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Intro slide
- An essay on the shaking palsy
- Outline 1
- Difference between parkinsonism and PD
- Parkinsonism vs. Parkinson disease
- The six cardinal features of parkinsonism
- Defining Parkinson disease
- Definition of PD
- Clinical definition of Parkinson disease
- Pathological and biochemical basis of PD
- Pathological and biochemical definition of PD
- Lewy bodies in a SN pigmented neuron
- Staging of brain pathology related to sporadic PD
- More pathological and biochemical features of PD
- Diagram of the nigrostriatle dopamine neurons
- Horizontal slice through the brain
- Neuroimaging of PD
- Definition of PD by PET/SPECT scans
- FDOPA PET in PD
- FPCIT/PET
- Outline 2
- Age-specific prevalence in PD
- Age specific prevalence of incidental Lewy bodies
- Age- and sex- specific incidence rate of PD
- Prevalence of PD in the USA
- Projections for PD prevalence in the USA
- Outline 3
- Consequences of putaminal DA deficiency
- Metabolic activities in the brain in PD
- Outline 4
- Rate of clinical progression
- Gene localizations identified for PD
- The very "benign" parkinsonian patient
- Outline 5
- Parkinsonian states
- Secondary Parkinson
- Parkinson plus syndromes
- Heredodegenerative parkinsonism
- Clinical instruments to measure severity of PD
- Unified PD rating scale (UPDRS)
- UPRS determine cause of parkinsonism (I)
- UPRS determine cause of parkinsonism (II)
- UPRS determine cause of parkinsonism (II)
- Outline 6
- Dopaminergic agents
- Biochemical pathway for formation of dopamine
- Non-dopaminergic agents for motor symptoms
- Non-dopaminergic agents for non-motor symptoms
- PD is more then loss of striatal dopamine
- Non-motor problems of Parkinson's disease (I)
- Non-motor problems of Parkinson's disease (II)
- Treatment strategy
- Complications of therapy
- Motor complications appearance
- Frequency of motor response complications
- Dopamine receptors
- Outline 7
- Composite of progression of PD
- Slowing progression
- Neuroprotective therapy
- Etiology of PD
- Thank you
Topics Covered
- Clinical symptoms of PD
- Current knowledge on pathological mechanisms
- Epidemiological facts
- Genetic factors
- Clinical management and DA replacement therapy
- Importance of nonmotor symptoms
- Future treatment directions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Fahn, S. (2007, October 1). Parkinson disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/CCXR9116.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stanley Fahn has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.