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- Epidemiology and Risk Factors
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41 min
1. The changing prevalence of asthma- Dr. Deborah Jarvis
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29 min
2. Recent advances in asthma genetics- Prof. Miriam Moffatt
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35 min
3. Asthma: an epidemic caused by epigenetics?- Prof. David Schwartz
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30 min
4. Role of the microbiota in asthma- Prof. B. Brett Finlay
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32 min
5. Diet and asthma- Prof. Lewis Smith
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43 min
6. Obesity and asthma- Prof. Anne Dixon
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35 min
7. Occupational asthma: management beyond the textbooks- Prof. Paul Cullinan
- Clinical Phenotypes
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42 min
8. The origins of asthma- Prof. Peter Sly
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46 min
9. Pre-school wheeze- Prof. Andrew Bush
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50 min
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24 min
11. Smoking asthmatics- Prof. Neil Thomson
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27 min
12. Aspirin exacerbated respiratory disease- Prof. Chris Corrigan
- Mechanisms of Asthma
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48 min
13. Advances in asthma: airway inflammation- Prof. William Busse
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48 min
14. The role of mast cells in asthma- Prof. Peter Bradding
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67 min
15. Dendritic cells in asthma- Prof. Bart Lambrecht
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30 min
16. The airway smooth muscle in asthma- Prof. Judith Black
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49 min
17. Role of virus infection in asthma 1- Prof. Sebastian Johnston
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27 min
18. Role of virus infection in asthma 2- Prof. Sebastian Johnston
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51 min
19. Severe asthma: characterisation, mechanisms & treatment- Prof. Fan Chung
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46 min
20. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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26 min
21. Macrophage in asthma- Prof. Douglas Robinson
- Diagnosis of Asthma
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70 min
22. Physiology of asthma and involvement of small airways- Prof. Charles G. Irvin
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27 min
23. Induced sputum in asthma- Prof. Antonio Spanevello
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61 min
- Therapy and Management
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41 min
25. Pulmonary drug delivery- Prof. Anthony J. Hickey
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32 min
26. The management of chronic asthma- Prof. Mark Fitzgerald
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21 min
27. Inhaled corticosteroids and beta2-agonists- Dr. Omar S. Usmani
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20 min
28. Management of "difficult asthma"- Prof. Elisabeth Bel
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47 min
29. Management of acute exacerbations of asthma- Dr. Chris Fanta
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34 min
30. Non-pharmacological treatments for asthma- Prof. Neil Thomson
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45 min
31. Asthma: beyond the prescription- Prof. Martyn Partridge
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45 min
32. New drugs for asthma- Prof. Peter Barnes
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24 min
33. Anti-IgE therapy for asthma- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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45 min
34. New drugs for asthma- Prof. Peter Barnes
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35 min
35. Asthma phenotypes in children- Prof. Andrew Bush
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40 min
36. Steroid resistance in asthma: mechanisms and potential therapies- Prof. Ian Adcock
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42 min
37. Severe asthma in children- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- Epigenetic marks and risk of developing asthma
- Epigenetic: control of gene expression
- Epigenetic mechanisms
- In utero diet can alter the epigenome
- Aguti gene
- Aging and epigenetic marks
- Histone modifications and innate immunity
- CpG motif methylation
- Asthma is a major public health problem
- Epigenetics and airway immunology
- DNA methylation changes and asthma
- High vs. low methylation diet
- Airway resistance in high vs. low methylation diet
- Epigenetics and asthma
- Transgenerational transmission of asthma to F2 (1)
- Transgenerational transmission of asthma to F2 (2)
- 82 hypermethylated loci among HMD progeny
- Runx3 and airway disease
- New biological targets
- In utero folate supplementation and asthma
- Asthma and epigenetics in humans
- Sib pair asthma study - preliminary analysis
- Global methylation patterns
- Genome-wide DMR
- Distribution of 873 DMRs from CpG islands
- Hypomethylation of GATA3
- Hypomethylation of MUC5B
- Hypermethylation of NOS2
- Additional approaches
- Summary
- Acknowledgment
Topics Covered
- Genetic and biological determinants of diseases influenced by the environment
- Epigenetics
- Epigenetic mechanisms can be influenced by environmental exposures and aging
- Histone modifications and innate immunity
- Asthma is a major public health problem
- Epigenetics and airway immunology
- DNA methylation changes and asthma
- Runx3 and airway disease
- In utero folate supplementation and asthma
- Sib pair asthma study
- Preliminary analysis
- Global methylation patterns: asthmatics vs. nonasthmatics
- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs
- Hypermethylation of NOS2 is associated with concordant asthma
- Asthma: an epidemic caused by epigenetics?
Links
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Talk Citation
Schwartz, D. (2020, October 11). Asthma: an epidemic caused by epigenetics? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/CNGX8188.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Schwartz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
