• Epidemiology and Risk Factors
• 41 min
  1. The changing prevalence of asthma

  • Dr. Deborah Jarvis
• 29 min
  2. Recent advances in asthma genetics

  • Prof. Miriam Moffatt
• 35 min
  3. Asthma: an epidemic caused by epigenetics?

  • Prof. David Schwartz
• 30 min
  4. Role of the microbiota in asthma

  • Prof. B. Brett Finlay
• 32 min
  5. Diet and asthma

  • Prof. Lewis Smith
• 43 min
  6. Obesity and asthma

  • Prof. Anne Dixon
• 35 min
  7. Occupational asthma: management beyond the textbooks

  • Prof. Paul Cullinan
• Clinical Phenotypes
• 42 min
  8. The origins of asthma

  • Prof. Peter Sly
• 46 min
  9. Pre-school wheeze

  • Prof. Andrew Bush
• 50 min
  10. Updates on the management of difficult asthma in school-aged children

  • Prof. Andrew Bush
• 24 min
  11. Smoking asthmatics

  • Prof. Neil Thomson
• 27 min
  12. Aspirin exacerbated respiratory disease

  • Prof. Chris Corrigan
• Mechanisms of Asthma
• 48 min
  13. Advances in asthma: airway inflammation

  • Prof. William Busse
• 48 min
  14. The role of mast cells in asthma

  • Prof. Peter Bradding
• 67 min
  15. Dendritic cells in asthma

  • Prof. Bart Lambrecht
• 30 min
  16. The airway smooth muscle in asthma

  • Prof. Judith Black
• 49 min
  17. Role of virus infection in asthma 1

  • Prof. Sebastian Johnston
• 27 min
  18. Role of virus infection in asthma 2

  • Prof. Sebastian Johnston
• 51 min
  19. Severe asthma: characterisation, mechanisms & treatment

  • Prof. Fan Chung
• 46 min
  20. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 26 min
  21. Macrophage in asthma

  • Prof. Douglas Robinson
• Diagnosis of Asthma
• 70 min
  22. Physiology of asthma and involvement of small airways

  • Prof. Charles G. Irvin
• 27 min
  23. Induced sputum in asthma

  • Prof. Antonio Spanevello
• 61 min
  24. Advances in asthma: the role of exhaled nitric oxide in the assessment and management of asthma

  • Prof. Robin Taylor
• Therapy and Management
• 41 min
  25. Pulmonary drug delivery

  • Prof. Anthony J. Hickey
• 32 min
  26. The management of chronic asthma

  • Prof. Mark Fitzgerald
• 21 min
  27. Inhaled corticosteroids and beta2-agonists

  • Dr. Omar S. Usmani
• 20 min
  28. Management of "difficult asthma"

  • Prof. Elisabeth Bel
• 47 min
  29. Management of acute exacerbations of asthma

  • Dr. Chris Fanta
• 34 min
  30. Non-pharmacological treatments for asthma

  • Prof. Neil Thomson
• 45 min
  31. Asthma: beyond the prescription

  • Prof. Martyn Partridge
• 45 min
  32. New drugs for asthma

  • Prof. Peter Barnes
• 24 min
  33. Anti-IgE therapy for asthma

  • Dr. Andrew Menzies-Gow
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  34. New drugs for asthma

  • Prof. Peter Barnes
• 35 min
  35. Asthma phenotypes in children

  • Prof. Andrew Bush
• 40 min
  36. Steroid resistance in asthma: mechanisms and potential therapies

  • Prof. Ian Adcock
• 42 min
  37. Severe asthma in children

  • Prof. Andrew Bush

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Epigenetic marks and risk of developing asthma
3. Epigenetic: control of gene expression
4. Epigenetic mechanisms
5. In utero diet can alter the epigenome
6. Aguti gene
7. Aging and epigenetic marks
8. Histone modifications and innate immunity
9. CpG motif methylation
10. Asthma is a major public health problem
11. Epigenetics and airway immunology
12. DNA methylation changes and asthma
13. High vs. low methylation diet
14. Airway resistance in high vs. low methylation diet
15. Epigenetics and asthma
16. Transgenerational transmission of asthma to F2 (1)
17. Transgenerational transmission of asthma to F2 (2)
18. 82 hypermethylated loci among HMD progeny
19. Runx3 and airway disease
20. New biological targets
21. In utero folate supplementation and asthma
22. Asthma and epigenetics in humans
23. Sib pair asthma study - preliminary analysis
24. Global methylation patterns
25. Genome-wide DMR
26. Distribution of 873 DMRs from CpG islands
27. Hypomethylation of GATA3
28. Hypomethylation of MUC5B
29. Hypermethylation of NOS2
30. Additional approaches
31. Summary
32. Acknowledgment

Topics Covered

• Genetic and biological determinants of diseases influenced by the environment
• Epigenetics
• Epigenetic mechanisms can be influenced by environmental exposures and aging
• Histone modifications and innate immunity
• Asthma is a major public health problem
• Epigenetics and airway immunology
• DNA methylation changes and asthma
• Runx3 and airway disease
• In utero folate supplementation and asthma
• Sib pair asthma study
• Preliminary analysis
• Global methylation patterns: asthmatics vs. nonasthmatics
• Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs
• Hypermethylation of NOS2 is associated with concordant asthma
• Asthma: an epidemic caused by epigenetics?

Links

Series:

• Advances in Asthma

Categories:

• Cell Biology
• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Respiratory Diseases

Talk Citation

Publication History

• Published on December 29, 2011
• Reviewed on October 11, 2020

Financial Disclosures

• Prof. David Schwartz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.