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• 52 min
  1. Principles of cytokine-receptor interactions and signal transduction

  • Dr. Xiaoxia Li
• 47 min
  2. Toll-like receptor signalling during infection and inflammation

  • Prof. Luke O'Neill
• 74 min
  3. Cytokines and CD4 T Cells: dance partners at the immunology ball

  • Dr. William E. Paul
• 38 min
  4. The gamma c family of cytokines

  • Dr. Warren J. Leonard
• 29 min
  5. Interleukin-6: back to the future

  • Prof. Tadamitsu Kishimoto
• 59 min
  6. Regulation of the immune response to pathogens 1

  • Prof. Anne O’Garra
• 33 min
  7. Regulation of the immune response to pathogens 2

  • Prof. Anne O’Garra
• 23 min
  8. IL-17 cytokine family and receptors

  • Prof. Chen Dong
  • Dr. Seon Hee Chang
• 40 min
  9. The b common (bc) family of cytokines, receptors and ligands

  • Prof. Angel Lopez
  • Dr. Timothy Hercus
• 29 min
  10. TNF superfamily cytokines and receptors in the healthy and diseased immune system

  • Dr. Richard Siegel
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 49 min
  12. IL-1 as a key inflammatory regulator in autoinflammatory diseases

  • Dr. Raphaela Goldbach-Mansky
• 58 min
  13. Signaling for the interferon family of receptors and ligands and clinical implications

  • Prof. Leonidas Platanias
• 45 min
  14. Interferons as antivirals: translating basic research into clinical application

  • Prof. Eleanor N. Fish
• 49 min
  15. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 22 min
  16. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  17. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 49 min
  18. Receptor identification for alarmins and DAMPs

  • Dr. Joost J. Oppenheim
• 41 min
  19. Assays for cytokines and cytokine assay performance 1

  • Prof. Theresa Whiteside
• 39 min
  20. Assays for cytokines and cytokine assay performance 2

  • Prof. Theresa Whiteside
• 23 min
  21. Interleukin-7 and T cells

  • Dr. Scott Durum
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  22. Assays for cytokines and cytokine assay standardization

  • Prof. Theresa Whiteside

Printable Handouts

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Navigable Slide Index

1. Introduction
2. The TNF-TNFR superfamily: history
3. Genomics of the TNF/TNFR superfamily
4. The TNF/TNFR superfamily: overview
5. The TNF/TNFR superfamily: main areas of action
6. TNF-receptor superfamily signaling types
7. TNF-SF structure-function: TNF ligands
8. TNF receptors: extracellular domains
9. Ligand:Receptor binding
10. TNF-SF structure-function: Death domain
11. TNF-SF structure-function: TRAF domain
12. Fas and TNFR family members pre-association
13. Use of the PLAD by other non-classical ligands
14. Apoptosis triggered through DISC recruitment
15. FAS-FADD crystal structure
16. Fas engagement induces receptor clustering
17. Gene expression through TRAF proteins
18. Dual signaling by TNF receptors
19. Regulation by dynamic expression of ligands
20. TNF-SF functions: lymph node development
21. TNF-SF functions: innate immunity enhancement
22. TNF-SF functions: B cell co-stimulation
23. TNF-SF functions: T-cell co-stimulation
24. TNFR in T cell expansion and contraction
25. TL1A-DR3 interactions critical for effector T cells
26. Negative regulation through apoptosis induction
27. Multiple pathways lead to programmed cell death
28. TNF-SF functions: osteoclast development
29. Molecular mechanisms of genetic diseases
30. ALPS - genetic defects in the Fas pathway
31. Fas death domain mutants
32. Extracellular Fas mutations
33. Therapeutic uses of TNF-SF blockade
34. Other anti-inflammatory agents against TNF-SF
35. Review papers for further reading

Topics Covered

• Genomics of the TNF/TNFR superfamily
• TNF/TNFR signaling types
• Various domains of TNFR
• TNF ligands and receptor binding
• Fas and the TNFR family
• Apoptosis through DISC recruitment
• FAS-FADD crystal structure
• Gene expression through TRAF proteins and regulation by dynamic expression of ligands
• Lymph node development
• Innate immunity enhancement
• B & T cells and the TNFR superfamily
• Multiple programmed cell death pathways
• Osteoclast development
• Molecular mechanisms of genetic diseases and defects in the Fas pathway
• Fas intra and extracellular mutations
• Therapeutics and anti-inflammatory uses of TNF superfamily blockade

Links

Series:

• Cytokines

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on December 5, 2011

Financial Disclosures

• Dr. Richard Siegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.