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1. Introduction
2. Environmental change and the brain
3. Auditory processing
4. Neurophysiological auditory assessment
5. Typical sensory evoked potential testing
6. Higher brain functions
7. Imaging the entire brain
8. But...
9. Some parts are dark while others are in daylight
10. The lighting pattern changes with time
11. Human electrophysiological functional imaging
12. The inverse problem of source estimation
13. The inverse problem
14. Assumptions to solve the inverse problem
15. Source current density estimation
16. LORETA validation
17. LORETA fMRI equivalence faces
18. Recording scalp electrical activity
19. Dyslexia
20. Dyslexia study
21. Controls distinguish speech temporal cues
22. Dyslexics show "locked" on the left activity
23. Dyslexics distinguish speech temporal cues
24. ADHD
25. In the NoGo condition of a Go/NoGo task
26. Current density to NoGo stimuli during N2/P3
27. Significance of current density differences
28. PBA
29. Current density in PBA-preTx and PBA-DM/Q (1)
30. Current density in PBA-preTx and PBA-DM/Q (2)
31. Summary of SnPM comparisons
32. Conclusions
33. Summary
34. Overall summary
35. Thank you

Topics Covered

• Hearing is the primary modality of language and memory
• Electrophysiological functional imaging is a direct manifestation of brain activity
• Electrophysiological functional imaging has temporal resolution in the millisecond scale
• The inverse problem of intracranial sources of scalp-recorded potentials is ill-posed
• Estimate intracranial sources requires assumptions on head and nature of sources
• Source current density estimation requires the least number of assumptions
• Dyslexia
• ADHD
• Pseudobulbar Affect disorders
• Quantitative measures of spatiotemporal distributions of activity show sensitivity at the population level and clinical promise at the individual patient level

Links

Categories:

• Methods
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Pratt, H. (2011, November 1). Neurophysiological functional imaging of the auditory system for evaluation of higher brain functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 25, 2022, from https://hstalks.com/bs/2135/.

Publication History

• Published on November 1, 2011

Financial Disclosures

• Prof. Hillel Pratt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.