• View the Talks
• 52 min
  1. Traumatic brain injury: from the ball field to the battlefield

  • Prof. Alan Faden
• 29 min
  2. Avoiding missed diagnosis of mild traumatic brain injury

  • Dr. John Bedolla
• 81 min
  3. Basic mechanisms of spinal cord injury (SCI)

  • Prof. Edward D. Hall
• 38 min
  4. Neuroinflammation and spinal cord injury

  • Prof. Phillip Popovich
• 46 min
  5. Experimental models for assessing treatments for spinal cord injury

  • Dr. Mark Habgood
• 52 min
  6. Experimental approaches to developing and evaluating novel treatments for TBI and SCI

  • Prof. W. Dalton Dietrich
• 62 min
  7. The treatment of spinal cord injury: past, present and future

  • Prof. James Fawcett
• 26 min
  8. The management of the patient with an acute spinal cord injury

  • Dr. Doug Brown
• 32 min
  9. Promoting neuroplasticity for functional restoration after SCI

  • Prof. Edelle Field-Fote
• 40 min
  10. Physical rehabilitation after spinal cord injury: maximizing function

  • Prof. Jennifer Hastings
• 28 min
  11. Therapies for spinal cord injury: perspective from industry

  • Dr. Andrew Blight
• 28 min
  12. Spinal cord injury: some reflections on living with tetraplegia

  • Prof. Jonathan Cole
• 25 min
  13. Coping beyond adversity: living with a spinal cord injury

  • Mr. Gary Allsop
• 34 min
  14. Identifying the trauma footprint of acquired brain injury

  • Dr. Christine Durham
• 32 min
  15. Acquiring better insight into what it's like to have acquired brain injury

  • Dr. Christine Durham
• 25 min
  16. Molecular imaging in epilepsy

  • Prof. Matthias Koepp
• 17 min
  17. Spinal cord injury and physical activity: transforming rehabilitation

  • Prof. Mary Galea
• 44 min
  18. Rehabilitation of military related neurotrauma

  • Dr. Michael Yochelson
• 41 min
  19. Spinal cord injury in natural disasters

  • Prof. Colleen O'Connell

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview
3. An industry perspective on CNS trauma (1)
4. An industry perspective on CNS trauma (2)
5. "Translation" to clinical research
6. Preclinical evidence wish list
7. The animal model problem
8. "Effective" treatments for experimental SCI
9. Against a small but significant counter-current
10. Animal SCI studies of "available" drugs
11. The regulatory path - a linear view
12. The regulatory path - realistic view
13. The challenge of development
14. Setting the primary endpoint bar in SCI
15. Reducing the noise
16. Where the light falls in acute SCI
17. What have we learned?
18. Outlook
19. Medical advance continues
20. In closing

Topics Covered

• The problems associated with developing therapies for acute spinal cord injury
• Need for reliable animal models
• Too many approaches appear to work
• Difficulties inherent in the clinical trial process
• The importance of establishing a clinically meaningful effect
• Defining useful primary endpoints

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 27, 2011

Financial Disclosures

• Dr. Andrew Blight, Full time employee and stockholder of Acroda Therapeutics, Inc.