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1. Introduction
2. Microbiota role in Salmonella infection
3. Microbial community composition in humans
4. Mammalian intestine phylum
5. Microbiota in the large intestine and diarrhea
6. Colonization resistance
7. Acute Salmonella diarrhea
8. Salmonella Typhimurium infection pathway
9. Streptomycin mouse model
10. Role of TTSS-1
11. Mechanisms eliciting inflammation
12. Reasons for inflammation
13. Salmonella benefits from acute diarrhea
14. Inflamed mucosa: glyco-conjugates
15. Inflamed mucosa: lipocalin-2
16. Inflamed mucosa: tetrathionate
17. Mechanisms are not specific for Salmonella
18. Terminating the primary Salmonella infection
19. Pathogen elimination
20. Adapting streptomycin mouse model
21. Resolving acute infection
22. Role of LPS-specific sIgA
23. sIgA protection mechanism
24. sIgA prohibits epithelium access
25. Does sIgA eliminate the pathogen from stool?
26. Microbiota role (1)
27. Microbiota role (2)
28. Microbiota eliminates pathogen
29. Verifying microbiota transfer
30. Complementary functions of microbiota and sIgA
31. Protection evolution and possible treatment
32. Acknowledgments

Topics Covered

• In Salmonella diarrhea the pathogen engages in a dense network of interactions with the commensal gut microbiota and the host's intestinal mucosa as well as the gut associated immune system
• Recent progress has allowed first insights into the molecular mechanisms driving these complex interaction networks

Links

Series:

• Microbiota

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Hardt, W. (2011, September 27). Salmonella diarrhea: contributions from the microbiota, the pathogen and the host [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/2098/.
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Publication History

• Published on September 27, 2011

Financial Disclosures

• Prof. Dr. Wolf-Dietrich Hardt has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.