• Overview
• 34 min
  1. An introduction to epilepsy

  • Prof. Steven Schachter
• Epidemiology
• 38 min
  2. Incidence, prevalence, and risk factors for epilepsy, and mortality

  • Dr. Dale Hesdorffer
• Diagnosis and Medical Management
• 29 min
  3. Classification system of seizures and epilepsy

  • Dr. Joseph Sirven
• 43 min
  4. Epilepsy in children

  • Dr. Elaine Wirrell
• 25 min
  5. Molecular imaging in epilepsy

  • Prof. Matthias Koepp
• 52 min
  6. Principles of electroencephalography

  • Prof. Donald Schomer
• 54 min
  7. Electroencephalography and epilepsy

  • Prof. Donald Schomer
• 39 min
  8. Pharmacological treatment

  • Prof. Dieter Schmidt
• 45 min
  9. Diagnosis and treatment for psychogenic nonepileptic seizures

  • Dr. W. Curt LaFrance, Jr.
• 41 min
  10. Status epilepticus

  • Prof. Daniel Lowenstein
• 47 min
  11. Anti-seizure drugs: discovery and development

  • Dr. Roger Porter
• Surgery and Brain Stimulation
• 46 min
  12. Epilepsy

  • Prof. Gregory D. Cascino
• 30 min
  13. Therapeutic devices for epilepsy

  • Dr. Robert Fisher
• Non-pharmacological Treatments
• 21 min
  14. Alternative therapies

  • Prof. Steven Schachter
• Psychosocial Aspects
• 37 min
  15. Epilepsy stigma and quality of life

  • Prof. Ann Jacoby
• Genetics and Neurobiology
• 57 min
  16. Genetic influences on human epilepsy

  • Prof. Russell J. Buono
• 68 min
  17. Epileptogenesis

  • Dr. Susan T. Herman
• 41 min
  18. Animal models of seizures and epilepsy

  • Dr. Wolfgang Löscher
• Global Burden of Epilepsy
• 32 min
  19. The global burden of epilepsy

  • Prof. Ley Sander
• Archived Lectures *These may not cover the latest advances in the field
• 48 min
  20. Epilepsy in children

  • Dr. Gregory L. Holmes

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Why we need animal models
3. Maximal electroshock seizure (MES) test
4. PTZ seizure test
5. Discovery of new AEDs
6. Models of epilepsy or epileptic seizures
7. Models for specific types of epilepsy
8. The kindling model of temporal lobe epilepsy
9. Anticonvulsant spectrum of AEDs
10. Other indications of approved AEDs
11. Top 10 therapeutic classes by US sales
12. Discovery of new AEDs - conclusions
13. Animal testing models and antiepileptic drugs
14. Specific models for pharmacoresistant seizures
15. Animal models of drug-resistant epilepsy
16. AED responders vs. non-responders
17. Mechanisms of drug resistance in epilepsy
18. The NIH anticonvulsant screening project
19. Evaluating changes in new AEDs efficacy
20. Efficacy of new AEDs during chronic treatment
21. Adverse effects of AED (epileptic/non-epileptic) (1)
22. Adverse effects of AED (epileptic/non-epileptic) (2)
23. Estimating effective AED plasma concentration (1)
24. Estimating effective AED plasma concentration (2)
25. Antiepileptogenic/disease-modifying treatments
26. Epilepsy development, progression, intervention
27. Testing antiepileptogenic drug potential
28. Future goals for therapeutic intervention
29. Using antiepileptic drugs for antiepileptogenesis
30. Therapeutic intervention - rational strategies
31. Rational strategies for antiepileptogenesis
32. GABA receptors during epileptogenesis-excitatory
33. Modification of epileptogenesis by Bumetanide
34. Summary
35. Acknowledgments

Topics Covered

• Diverse models available
• Invaluable preclinical approach for discovery of new treatments for epilepsy
• Specific models for pharmacoresistant seizures
• Models for the discovery of epilepsy-preventing drugs

Links

Series:

• Animal Models in Biomedical Research
• Epilepsy and Seizures

Categories:

• Methods
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 13, 2011

Financial Disclosures

• Dr. Wolfgang Löscher has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.