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1. Introduction
2. Talk overview
3. Calcium - the beginning
4. Calcium signalling: the beginning
5. Calcium ions are imperatively important for life
6. Calcium signalling - the idea is born
7. Calcium signalling - early discoveries (1)
8. Calcium signalling - early discoveries (2)
9. Patch-clamp and fluorescent calcium indicators
10. Diversity and versatility of calcium probes
11. Patch-voltage-clamp and calcium indicators
12. Calcium as a universal signalling molecule
13. Calcium signalling in neurones and neuroglia
14. Calcium provides substrate for glial excitability
15. Voltage-gated calcium channels
16. Calcium currents in glial cells
17. Calcium channel localization in glial cells
18. Ligand-gated calcium channels
19. Bergman glial cells express AMPA receptors
20. ER provides a substrate for glial excitability
21. InsP3-mediated Ca signalling in glial cells
22. Fluorescent thapsigargin in cultured astrocytes
23. Resting Ca concentration in the ER of astroglia
24. Expression of InsP3 receptors in glial cells
25. Calcium signalling in neurones and glia
26. ATP triggers calcium release in glial cells
27. InsP3 triggers Ca efflux from astroglial ER
28. Astrocytes express ryanodine receptors
29. Depletion of ER store triggers Ca entry
30. Store-operated Ca is present in all glia types (1)
31. Store-operated Ca is present in all glia types (2)
32. Ca release/store-operated Ca entry dissociation
33. Two functionally different compartments in the ER
34. Expression of TRP channels in glial cells
35. Glial cells response to neuronal activity
36. Synaptically evoked local calcium signals in glia
37. Inhibiting neurons blocks Ca signals in glia
38. Synaptic Ca signalling occur in microdomains
39. Glu induces Ca release from intracellular stores
40. Heparin inhibits Glu-induced Ca signalling
41. mGluR5 are expressed in Bergmann glia
42. Stimulation of glial cells triggers Ca waves
43. Astroglial calcium waves
44. Mechanisms of glial Ca wave propagation
45. Conclusions

Topics Covered

• How calcium signalling was discovered
• Principles of calcium signalling
• Calcium signalling in neuroglia
• Voltage- and ligand-gated channels
• Endoplasmic reticulum calcium store
• Store-operated calcium entry
• Calcium signals in neuronal-glial interactions
• Glial calcium waves

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.