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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Epilepsy - definition
- Epilepsy - common mechanisms
- Epileptogenesis
- Etiology of epilepsy
- Epileptogenic process
- Epileptogenesis schematic
- Acute symptomatic seizures
- Electrographic seizure - EEG recording
- Recurrence of seizures over time
- Pathophysiology of acute symptomatic seizures
- Latent period
- Late seizures and epilepsy
- Animal models of epileptogenesis (1)
- Animal models of epileptogenesis (2)
- Pilocarpine model
- Mossy fiber sprouting after pilocarpine SE
- Kainate model
- Seizures after kainate SE
- Kindling model
- Fluid percussion injury model
- Progressive MRI changes in epileptogenesis
- Late posttraumatic seizures
- Risk of epilepsy after brain insults
- Risk of epilepsy after brain injury (1)
- Risk of epilepsy after brain injury (2)
- Risk of epilepsy after TBI
- Post-traumatic seizures
- Recurrence risk after seizures in TBI
- Incidence of seizures after stroke
- Stroke
- Methodological flaws
- Seizure-free patients after stroke
- Stroke severity and seizures
- Seizures by stroke subtype
- Seizures by infarct subtype
- Risk of late seizures
- Seizure incidence and neurosurgical procedures
- Seizure incidence and brain tumor
- Seizure incidence and CNS infection
- Seizure incidence and febrile seizures
- Status epilepticus - definitions
- Status epilepticus & epilepsy
- Status epilepticus - precipitants
- Clinical trials for prevention of epilepsy
- Epilepsy prophylaxis vs. treatment trials
- AEG study design
- Trial populations
- Subject selection
- Trial populations - other factors
- Drug options to use in a prophylaxis trial
- Treatment time window
- Trial endpoints (1)
- Trial endpoints (2)
- Previous antiepileptogenesis trials
- Epilepsy prophylaxis trials - traumatic brain injury
- Epilepsy prophylaxis trials - other risk factors
- Existing AEG trials
- AEG studies limitations
- Prevention of late seizure after TBI
- Seizure prevention trials after TBI
- Future directions
- Monitoring epileptogenesis
- Monitoring epileptogenesis-potential techniques
- Biomarkers for epileptogenesis
- Inclusion and validation of biomarkers
- Interictal Epileptiform Discharges (IED)
- IEDs - limitations
- Transcranial Magnetic Stimulation
- Neuroimaging may help predict epilepsy
- MRI may help predict epilepsy
- Future studies to prevent epilepsy
Topics Covered
- Introduction
- Causes of epilepsy
- Epileptogenesis
- Initial insult / Acute symptomatic seizures
- Latent period
- Late seizures
- Epilepsy
- Animal models of epileptogenesis
- Risk of epilepsy after brain insults
- Clinical trial design
- Review of prophylaxis trials
- Future directions
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Herman, S.T. (2011, May 3). Epileptogenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/ENQV4957.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Susan T. Herman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.