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1. Introduction
2. What will be covered in the talk
3. What will not be covered in the talk
4. Historic definition of status epilepticus (1876)
5. Older definitions of status epilepticus (1900's)
6. Evolution of status epilepticus definition
7. Generalized tonic/clonic seizure phases-duration
8. Duration of the ictal phase
9. Duration of most seizures
10. Proposed operational definition of SE
11. Proposed mechanistic definition of SE
12. Epidemiology/outcome
13. Outcome of SE by etiology (1)
14. Outcome of SE by etiology (2)
15. Risk factors for mortality
16. Mechanisms
17. SE related to factors that maintain\stop seizures
18. Seizure duration and Diazepam effective doses
19. Seizure duration and GABA(A)-R modulation
20. Ionic channel structure\function modulated in SE
21. Do seizure suppression mechanisms fail in SE?
22. Treatment
23. Initial management of SE
24. Treatment of SE circa 1990
25. Treatment of SE circa 2010
26. Four drug regimens compared for SE treatment
27. VA cooperative trial - main results
28. Sequential responses to treatment
29. Treating patients in RSE
30. Treatment response and outcomes in RSE (1)
31. Treatment response and outcomes in RSE (2)
32. Treatment response and outcomes in RSE (3)
33. Using Topiramate in RSE
34. Using inhalational anesthetic drugs in RSE
35. Using IV Levetiracetam in RSE
36. RSE - treatment recommendation
37. RSE treatment endpoint
38. Pre-hospital therapy
39. Pre-hospital treatment of SE
40. PHTSE - study design
41. PHTSE - final results
42. PHTSE - patient disposition
43. PHTSE - main questions answered
44. IM Midazolam vs. IV Lorazepam
45. NETT network
46. RAMPART - study design
47. RAMPART - autoinjectors and drug dosage
48. Take home messages

Topics Covered

• Generalized status epilepticus
• Evolution of the definition of status epilepticus
• Epidemiological studies of status epilepticus
• Basic mechanisms of status epilepticus
• Treatment approaches for status epilepticus in the hospital and out-of-hospital settings

Links

Series:

• Epilepsy and Seizures

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on May 3, 2011

Financial Disclosures

• Prof. Daniel Lowenstein has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.