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1. Introduction
2. Targets of modulation
3. Membrane properties affecting neuronal excitability
4. K channel gene families
5. Ca channel gene families
6. Na channels gene families
7. The DHPG-induced mADP is voltage dependent
8. The DHPG-induced mADP is mediated by Cav2.3
9. DHPG modulates voltage-gated calcium currents
10. mGluR5 activation modulates Cav2.3 in oocytes
11. Modulation of calcium channels via NE receptors
12. Modulation activity in the thalamus
13. Thalamocortical circuitry
14. Voltage-dependent modulation of firing mode
15. Reticular activating system
16. Control of thalamocortical spiking by ACh and NE
17. Thalamocortical circuitry (2)
18. Long term plasticity of intrinsic excitability
19. Rapidly reversible effects of DHPG in hippocampus
20. Long-lasting effects of dopamine modulation
21. Activity-dependent modulation
22. Learning-related neuromodulation in Hermissenda
23. EPSP-spike potentiation
24. Long-term increases in excitability (1)
25. Long-term increases in excitability (2)
26. Excitability changes over time
27. Plasticity of action potential bursting (1)
28. Plasticity of action potential bursting (2)
29. Plasticity of action potential bursting (3)
30. Plasticity of action potential bursting (4)
31. Plasticity of action potential bursting (5)
32. Plasticity of action potential bursting (6)
33. Plasticity of action potential bursting (7)
34. Local control of excitability
35. Localized changes in neuronal excitability
36. Backpropagating action potentials
37. Modulation of backpropagating action potentials (1)
38. Modulation of backpropagating action potentials (2)
39. Modulation of activity-dependent backpropagation
40. Local modulation of excitability
41. Dendritic branches with strong/weak excitability
42. Conversion of a weak branch to strong excitability
43. Local modulation of excitability (2)
44. Modulation of the axon initial segment by DA
45. Increased calcium influx localized to the AIS
46. Activity-dependent movement of the AIS
47. Conclusions (1)
48. Conclusions (2)
49. References (1)
50. References (2)

Topics Covered

• Synaptic integration and action potential firing
• Neuromodulation
• Modulation of firing by activation of GPCRs
• Modulation by other mechanisms
• Targets of modulation
• Modulation activity in the thalamus
• Long-term plasticity of intrinsic excitability
• Local control of excitability

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on April 7, 2011

Financial Disclosures

• Prof. Nelson Spruston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.