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1. Introduction
2. Central pattern generators
3. Neuromodulators allow behavioral flexibility
4. Panulirus interruptus
5. The pyloric network
6. Recordings from pyloric network cells
7. Normal pyloric rhythm
8. Pyloric network is subject to vast neuromodulation
9. Effects of dopamine (DA) on the pyloric network
10. DA modifies firing by altering ionic currents
11. Isolated neurons activity
12. DA reduces I(A) evoked bursting in AB neuron
13. DA reduces I(A) in the AB neuron
14. Calcium entry reduction elicits AB bursting
15. DA reduces I(Ca) in AB neuron
16. Apamin blockade of I(K[Ca]) evokes AB bursting
17. Blocking I(CAN) blocks DA-induced bursting
18. More examples of blocking DA-induced bursting
19. Intracellular Ca2+ increase precedes oscillations
20. DA enhances I(h) and reduces a leak current
21. DA enhances I(K[V]) in AB neuron
22. Summary of DA effects on AB neuron
23. AB bursting induced by many transmitters
24. 5-HT acts by different mechanisms than DA
25. 5-HT - Blocking I(Na[p]) blocks AB bursting
26. 5-HT reduces a leak current
27. Summary- effects of DA and 5-HT on AB neuron
28. How DA inhibits PD neurons
29. PD neurons: inhibition by dopamine
30. DA enhances 4-AP-sensitive I(A) in PD neurons
31. DA enhance TEA-sensitive I(K[Ca]) in PD neurons
32. DA reduces I(Ca[V]) in PD neurons
33. Effects of DA on LP and PY neurons
34. How DA accelerates post-inhibitory rebound
35. DA excites PY neuron by reduction in I(A)
36. DA excites LP by I(A) decrease and I(h) increase
37. Known ionic targets of dopamine
38. DA affects many currents in each pyloric neuron
39. Dopamine affects synapse strength
40. Multiple effects of DA on different pyloric synapses
41. Effects of DA on pyloric synapses (1)
42. DA enhances LP inhibition of PD/AB pacemaker
43. Pre-synaptic actions of dopamine
44. Postsynaptic actions of DA
45. Effects of DA on pyloric synapses (2)
46. DA effects on synaptic strengths are complex
47. Conclusions
48. Acknowledgments

Topics Covered

• Central pattern generators
• Pyloric network in the stomatogastric ganglion
• Neuromodulation of the pyloric network by dopamine
• Ionic mechanisms of dopamine modulation
• Synaptic mechanisms of dopamine modulation
• Checks and balances in opposing actions of neuromodulation

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Harris-Warrick, R.M. (2011, February 28). Cellular mechanisms of neuromodulation in a small neural network [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/BQER5397.
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Publication History

• Published on February 28, 2011

Financial Disclosures

• Prof. Ronald M. Harris-Warrick has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.