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1. Introduction
2. The amount of iron in the body is tightly regulated
3. Definition of hemochromatosis
4. Diagnosis of iron overload
5. Key iron overload disorders (1)
6. Key iron overload disorders (2)
7. Hereditary hemochromatosis: endocrine disorder
8. Clinical aspects - The past
9. Clinical consequences
10. Survival curve of hereditary hemochromatosis
11. Diseases affecting patients survival
12. The effect of cirrhosis on patients' survival
13. Clinical aspects - The present
14. Mortality due to hereditary hemochromatosis
15. Mutations in the HFE gene and disease
16. Mutations in the HFE gene are common
17. Elevation of serum iron is common
18. The dilemma of elevated ferritin levels (1)
19. The dilemma of elevated ferritin levels (2)
20. Cross sectional population studies
21. The controversy of phenotypes and genotypes
22. Longitudinal population studies (1)
23. Longitudinal population studies (2)
24. Longitudinal population studies (3)
25. Longitudinal population studies (4)
26. The HealthIron sub-study
27. HealthIron clinic recruitment
28. Untreated hemochromatosis progression
29. Probability of serum ferritin rise in males
30. Probability of serum ferritin rise in females
31. Clinical penetrance
32. Iron overload-related disease (1)
33. Iron overload-related disease (2)
34. Compound heterozygotes
35. C282Y homozygotes with ferritin <1000
36. HFE and cancer
37. Genetic and environmental modifiers
38. CYBRD1: a new potent genetic modifier
39. Take home message
40. Iron-overload evaluation algorithms (1)
41. Iron-overload evaluation algorithms (2)

Topics Covered

• Hereditary haemochromatosis
• Iron metabolism
• Definition
• Diagnosis
• Clinical and biochemical penetrance
• Genetic and environmental modifiers
• Diagnostic algorithm

Links

Series:

• Gastroenterology and Hepatology

Categories:

• Diseases, Disorders & Treatments
• Genetics & Epigenetics
• Metabolism & Nutrition

Talk Citation

Olynyk, J.K. (2011, January 5). Hereditary hemochromatosis: what have we learnt from population studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 25, 2020, from https://hstalks.com/bs/1919/.

Publication History

• Published on January 5, 2011

Financial Disclosures

• Prof. John K. Olynyk has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.