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Printable Handouts
Navigable Slide Index
- Introduction
- The amount of iron in the body is tightly regulated
- Definition of hemochromatosis
- Diagnosis of iron overload
- Key iron overload disorders (1)
- Key iron overload disorders (2)
- Hereditary hemochromatosis: endocrine disorder
- Clinical aspects - The past
- Clinical consequences
- Survival curve of hereditary hemochromatosis
- Diseases affecting patients survival
- The effect of cirrhosis on patients' survival
- Clinical aspects - The present
- Mortality due to hereditary hemochromatosis
- Mutations in the HFE gene and disease
- Mutations in the HFE gene are common
- Elevation of serum iron is common
- The dilemma of elevated ferritin levels (1)
- The dilemma of elevated ferritin levels (2)
- Cross sectional population studies
- The controversy of phenotypes and genotypes
- Longitudinal population studies (1)
- Longitudinal population studies (2)
- Longitudinal population studies (3)
- Longitudinal population studies (4)
- The HealthIron sub-study
- HealthIron clinic recruitment
- Untreated hemochromatosis progression
- Probability of serum ferritin rise in males
- Probability of serum ferritin rise in females
- Clinical penetrance
- Iron overload-related disease (1)
- Iron overload-related disease (2)
- Compound heterozygotes
- C282Y homozygotes with ferritin <1000
- HFE and cancer
- Genetic and environmental modifiers
- CYBRD1: a new potent genetic modifier
- Take home message
- Iron-overload evaluation algorithms (1)
- Iron-overload evaluation algorithms (2)
Topics Covered
- Hereditary haemochromatosis
- Iron metabolism
- Definition
- Diagnosis
- Clinical and biochemical penetrance
- Genetic and environmental modifiers
- Diagnostic algorithm
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Talk Citation
Olynyk, J.K. (2011, January 5). Hereditary hemochromatosis: what have we learnt from population studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 28, 2021, from https://hstalks.com/bs/1919/.Publication History
Financial Disclosures
- Prof. John K. Olynyk has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Hereditary hemochromatosis: what have we learnt from population studies
Published on January 5, 2011
34 min
Other Talks in the Category: Metabolism & Nutrition
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