• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. List of neurodegenerative diseases
3. Beta-amyloid and tau proteins
4. Paired helical and straight tau filaments
5. Beta amyloid
6. Tau isoforms
7. Microtubule structure
8. Tau repeats bound to the inside of microtubules
9. Immunoblots of PHF-tau
10. Phosphorylation sites in PHF-tau
11. Tau phosphorylation
12. Neuropathological spectrum of tauopathies
13. Biochemical spectrum of tauopathies
14. Relevance of tau to the disease process
15. MAPT mutations
16. Stages of tau pathology
17. Grouping tau pathology according to age
18. Tau protein
19. Using experimental animal models
20. P301S tau light microscopic picture
21. P301S tau electromicroscopic picture
22. Immunoblot of mouse expressing P301S tau
23. Massive neurodegeneration in the spinal cord
24. Crossing mutant APP and P301S tau mice
25. Inducing tau pathology in Alz17 mice
26. Temporospatial spreading of tau pathology
27. Phosphorylation of tau - summary
28. Individual tau phosphorylation sites
29. Increased GSK-3-beta activity and tau pathology
30. Protein kinase inhibition and tau pathology
31. Protein kinase inhibition and motor symptoms
32. Phosphatase activity and tau pathology
33. Sodium selenate treatment
34. Summary
35. Future research areas

Topics Covered

• Alzheimer's disease
• Extracellular plaques
• Intracellular tangles
• Tau filaments
• Tau hyperphosphorylation
• Other tauopathies
• Mouse models of tauopathy
• Protein kinase inhibitors
• Protein phosphatase activators

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on December 14, 2010

Financial Disclosures

• Prof. Michel Goedert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.