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Printable Handouts
Navigable Slide Index
- Introduction
- List of neurodegenerative diseases
- Beta-amyloid and tau proteins
- Paired helical and straight tau filaments
- Beta amyloid
- Tau isoforms
- Microtubule structure
- Tau repeats bound to the inside of microtubules
- Immunoblots of PHF-tau
- Phosphorylation sites in PHF-tau
- Tau phosphorylation
- Neuropathological spectrum of tauopathies
- Biochemical spectrum of tauopathies
- Relevance of tau to the disease process
- MAPT mutations
- Stages of tau pathology
- Grouping tau pathology according to age
- Tau protein
- Using experimental animal models
- P301S tau light microscopic picture
- P301S tau electromicroscopic picture
- Immunoblot of mouse expressing P301S tau
- Massive neurodegeneration in the spinal cord
- Crossing mutant APP and P301S tau mice
- Inducing tau pathology in Alz17 mice
- Temporospatial spreading of tau pathology
- Phosphorylation of tau - summary
- Individual tau phosphorylation sites
- Increased GSK-3-beta activity and tau pathology
- Protein kinase inhibition and tau pathology
- Protein kinase inhibition and motor symptoms
- Phosphatase activity and tau pathology
- Sodium selenate treatment
- Summary
- Future research areas
Topics Covered
- Alzheimer's disease
- Extracellular plaques
- Intracellular tangles
- Tau filaments
- Tau hyperphosphorylation
- Other tauopathies
- Mouse models of tauopathy
- Protein kinase inhibitors
- Protein phosphatase activators
Links
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Therapeutic Areas:
Talk Citation
Goedert, M. (2010, December 14). The hyperphosphorylation of tau and Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/MYQM6207.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michel Goedert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.