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Navigable Slide Index

1. Introduction
2. List of neurodegenerative diseases
3. Beta-amyloid and tau proteins
4. Paired helical and straight tau filaments
5. Beta amyloid
6. Tau isoforms
7. Microtubule structure
8. Tau repeats bound to the inside of microtubules
9. Immunoblots of PHF-tau
10. Phosphorylation sites in PHF-tau
11. Tau phosphorylation
12. Neuropathological spectrum of tauopathies
13. Biochemical spectrum of tauopathies
14. Relevance of tau to the disease process
15. MAPT mutations
16. Stages of tau pathology
17. Grouping tau pathology according to age
18. Tau protein
19. Using experimental animal models
20. P301S tau light microscopic picture
21. P301S tau electromicroscopic picture
22. Immunoblot of mouse expressing P301S tau
23. Massive neurodegeneration in the spinal cord
24. Crossing mutant APP and P301S tau mice
25. Inducing tau pathology in Alz17 mice
26. Temporospatial spreading of tau pathology
27. Phosphorylation of tau - summary
28. Individual tau phosphorylation sites
29. Increased GSK-3-beta activity and tau pathology
30. Protein kinase inhibition and tau pathology
31. Protein kinase inhibition and motor symptoms
32. Phosphatase activity and tau pathology
33. Sodium selenate treatment
34. Summary
35. Future research areas

Topics Covered

• Alzheimer's disease
• Extracellular plaques
• Intracellular tangles
• Tau filaments
• Tau hyperphosphorylation
• Other tauopathies
• Mouse models of tauopathy
• Protein kinase inhibitors
• Protein phosphatase activators

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Goedert, M. (2010, December 14). The hyperphosphorylation of tau and Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/MYQM6207.
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Publication History

• Published on December 14, 2010

Financial Disclosures

• Prof. Michel Goedert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.