• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Ubiquitination vs. phosphorylation (1)
3. Ubiquitination vs. phosphorylation (2)
4. Ubiquitination vs. phosphorylation (3)
5. Ubiquitin-binding domains
6. Ubiquitination vs. phosphorylation (4)
7. Ubiquitin signaling in the NF-kappaB pathway
8. NF-kappaB signaling pathway
9. The biochemical pathway of IkB ubiquitination (1)
10. The biochemical pathway of IkB ubiquitination (2)
11. The IL-1R/toll-like receptor pathway
12. TRAF-6, Nemo-dependent IKK activation in vitro
13. Activation of IKK by TRAF6 requires two factors
14. TRAF6-regulated IKK activator-2
15. Ubc13 is required for IKK activation by IL-1beta
16. Catalytic activity of Ubc13
17. TRIKA1 = Ubc13/Uev1A
18. Domain organization of TRAFs
19. TRAF6 is a ubiquitin ligase
20. Polyubiquitin chains
21. K63-linked polyUb chains mediate IKK activation
22. Human ubiquitin genes
23. An inducible ubiquitin "knock-in" system
24. K63 is required for IKK activation by IL-1beta
25. TRIKA2 = TAK1/TAB1/TAB2
26. Ubiquitin activation of stress kinases
27. The proposed model
28. The CYLD and NEMO pathologies
29. Innate and adaptive immunity
30. Acknowledgement

Topics Covered

• Ubiquitination is a reversible covalent modification, akin to phosphorylation
• Ubiquitination regulates protein kinase activity through proteasome-independent mechanisms
• K63-linked polyubiquitination activates TAK1 and IKK in the NF-kappaB pathway
• Deubiquitination enzymes inhibit protein kinases in the NF-kappaB pathway
• Protein kinase regulation by ubiquitin is important in innate and adaptive immunity

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Zhijian 'James' Chen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.