• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The DNA molecule
3. Agents that damage the DNA
4. Endogenous DNA damage in mammalian cells
5. DSB repair pathways
6. The DNA damage response
7. Cellular responses to DNA damage
8. Localized DNA damage
9. Proteins recruitment to the DS break
10. Genomic instability syndromes
11. Ataxia-telangiectasia history
12. Ataxia-telangiectasia characteristics
13. ATM and DNA damage response
14. The ATM protein
15. ATM activation
16. ATM-mediated DNA damage responses
17. PI3-kinase-related protein kinases
18. p53 activation and stabilization by ATM
19. Research directions
20. ATM-mediated DNA damage response branches
21. A SPIKE map
22. Identification of ATM/ATR/DNA-PK substrates
23. Insights into the ATM-mediated DDR
24. Defective repair of DNA double strand breaks
25. ATM-mediated signaling facilitating DSB repair
26. Polynucleotide kinase 3'-phosphatase
27. ATM-mediated phosphorylation of PNKP
28. Allowing repair to happen within chromatin
29. ATM-dependent phosphorylation of KAP-1
30. ATM effects chromatin reorganization
31. ATM-mediated H2B monoubiquitination
32. DNA damage response and the ubiquitin family
33. Players in ubiquitin-related processes
34. Overlap between Ub arena and ATM substrates
35. Phosphoproteome dynamics after DNA damage
36. Damage-induced protein phosphorylation
37. Functional networks of phosphorylated proteins
38. Overlap between Ub, ATM and phosporylation
39. Functional screens for novel DDR players
40. Results of a functional screen
41. Summary

Topics Covered

• Endogenous DNA damage in mammalian cells
• DSB repair pathways
• Cellular responses to DNA damage
• Genomic instability syndromes
• Ataxia-telangiectasia
• The ATM protein
• ATM-mediated DNA damage responses
• A SPIKE map
• Defective repair of DNA double strand breaks
• Allowing repair to happen within chromatin
• DNA damage response and the ubiquitin family
• Players in ubiquitin-related processes
• Phosphoproteome dynamics after DNA damage
• Functional networks of phosphorylated proteins
• Overlap between Ub, ATM and phosporylation
• Functional screens for novel DDR players

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Shiloh, Y. (2011, July 5). The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2025, from https://doi.org/10.69645/KNEK3598.
Export Citation (RIS)

Publication History

• Published on July 5, 2011

Financial Disclosures

• Prof. Yosef Shiloh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.