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1. Introduction
2. The DNA molecule
3. Agents that damage the DNA
4. Endogenous DNA damage in mammalian cells
5. DSB repair pathways
6. The DNA damage response
7. Cellular responses to DNA damage
8. Localized DNA damage
9. Proteins recruitment to the DS break
10. Genomic instability syndromes
11. Ataxia-telangiectasia history
12. Ataxia-telangiectasia characteristics
13. ATM and DNA damage response
14. The ATM protein
15. ATM activation
16. ATM-mediated DNA damage responses
17. PI3-kinase-related protein kinases
18. p53 activation and stabilization by ATM
19. Research directions
20. ATM-mediated DNA damage response branches
21. A SPIKE map
22. Identification of ATM/ATR/DNA-PK substrates
23. Insights into the ATM-mediated DDR
24. Defective repair of DNA double strand breaks
25. ATM-mediated signaling facilitating DSB repair
26. Polynucleotide kinase 3'-phosphatase
27. ATM-mediated phosphorylation of PNKP
28. Allowing repair to happen within chromatin
29. ATM-dependent phosphorylation of KAP-1
30. ATM effects chromatin reorganization
31. ATM-mediated H2B monoubiquitination
32. DNA damage response and the ubiquitin family
33. Players in ubiquitin-related processes
34. Overlap between Ub arena and ATM substrates
35. Phosphoproteome dynamics after DNA damage
36. Damage-induced protein phosphorylation
37. Functional networks of phosphorylated proteins
38. Overlap between Ub, ATM and phosporylation
39. Functional screens for novel DDR players
40. Results of a functional screen
41. Summary

Topics Covered

• Endogenous DNA damage in mammalian cells
• DSB repair pathways
• Cellular responses to DNA damage
• Genomic instability syndromes
• Ataxia-telangiectasia
• The ATM protein
• ATM-mediated DNA damage responses
• A SPIKE map
• Defective repair of DNA double strand breaks
• Allowing repair to happen within chromatin
• DNA damage response and the ubiquitin family
• Players in ubiquitin-related processes
• Phosphoproteome dynamics after DNA damage
• Functional networks of phosphorylated proteins
• Overlap between Ub, ATM and phosporylation
• Functional screens for novel DDR players

Links

Series:

• Protein Phosphorylation

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Shiloh, Y. (2011, July 5). The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 18, 2019, from https://hstalks.com/bs/1889/.

Publication History

• Published on July 5, 2011

Financial Disclosures

• Prof. Yosef Shiloh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.